Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat
Effects of repeated electroconvulsive shock seizures and pilocarpine-induced status epilepticus on emotional behavior in the rat
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DOI：
10.1016/j.yebeh.2008.11.004
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发表时间：
2009-02-01
影响因子：
2.6
通讯作者：
Lukoyanov, Nikolai V.
中科院分区：
文献类型：
--
作者：
Cardoso, Armando;Carvalho, Liliana S.;Lukoyanov, Nikolai V.
癫痫患者常出现情感性症状。虽然这些行为并发症的病因尚不清楚，但与频繁或长期癫痫发作相关的脑损伤可能是导致这些并发症的原因之一。为了解决这个问题，我们研究了电惊厥(ECS)引起的反复短暂癫痫发作的行为后遗症，并将它们与匹罗卡品诱导的长时间癫痫持续状态(SE)的后遗症进行了比较。使用开场和高架正迷宫测试，我们检测到在接受ECS癫痫发作疗程的大鼠中，存在指示焦虑水平上升的行为变化。在这些动物中，恐惧条件反射也得到了加强。然而，与对照组相比，经历了SE的大鼠表现出较少的焦虑样行为，并且在恐惧条件反射中受到严重损害。这些结果支持这样一种观点，即由短暂反复发作或SE引起的脑损伤足以引起一些情感障碍。(C)2008 Elsevier Inc.保留所有权利。
Affective symptoms are frequently observed in patients with epilepsy. Although the etiology of these behavioral complications remains unknown, it is possible that brain damage associated with frequent or prolonged seizures may contribute to their development. To address this issue, we examined the behavioral sequelae of repeated brief seizures evoked by electroconvulsive shock (ECS) and compared them with those resulting from prolonged status epilepticus (SE) induced with pilocarpine. Using the open-field and elevated plus-maze tests, we detected the presence of behavioral alterations indicative of elevated levels of anxiety in rats that were administered a course of ECS seizures. Fear conditioning was also enhanced in these animals. However, the rats that had experienced SE exhibited less anxiety-like behavior than controls and were severely impaired in fear conditioning. These results support the notion that brain lesions caused by either brief repeated seizures or SE is Sufficient to induce some affective disturbances. (C) 2008 Elsevier Inc. All rights reserved.