Impulsivity and self-control during intertemporal decision making linked to the neural dynamics of reward value representation.
Impulsivity and self-control during intertemporal decision making linked to the neural dynamics of reward value representation.
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DOI：
10.1523/jneurosci.0919-12.2013
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发表时间：
2013-01-02
期刊：
影响因子：
--
通讯作者：
Braver TS
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文献类型：
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作者：
Jimura K;Chushak MS;Braver TS
冲动决策的一个特征是延迟奖励的折扣，通过选择偏好和与选择相关的大脑活动来证明。然而，延迟折扣也可能源于主观奖励值在预期即将到来的选择奖励时如何在大脑中动态表示。在目前的研究中，大脑活动连续监测人类参与者自由选择一个即时或延迟的主要液体奖励，然后等待指定的延迟之前消耗it.The腹内侧前额叶皮层（vmPFC）表现出的活动动力学的特征模式在延迟期间，以及调制过程中的选择，这是一致的主观价值的时间折扣编码。腹侧纹状体（VS）表现出类似的活动模式，但优先在冲动的个人。在前PFC（aPFC）中观察到延迟相关和选择激活的对比曲线，但在患者个体中选择性。多水平统计模型表明，vmPFC和aPFC施加调制，但相反，影响VS激活。这些结果将行为冲动和自我控制与未来奖励价值的动态进化神经表征联系起来，不仅在选择期间，而且在选择后的延迟期。
A characteristic marker of impulsive decision-making is the discounting of delayed rewards, demonstrated via choice preferences and choice-related brain activity. However, delay discounting may also arise from how subjective reward value is dynamically represented in the brain when anticipating an upcoming chosen reward. In the current study, brain activity was continuously monitored as human participants freely selected an immediate or delayed primary liquid reward and then waited for the specified delay before consuming it. The ventromedial prefrontal cortex (vmPFC) exhibited a characteristic pattern of activity dynamics during the delay period, as well as modulation during choice, that is consistent with the time-discounted coding of subjective value. The ventral striatum (VS) exhibited a similar activity pattern, but preferentially in impulsive individuals. A contrasting profile of delay-related and choice activation was observed in the anterior PFC (aPFC), but selectively in patient individuals. Multilevel statistical modeling indicated that both vmPFC and aPFC exerted modulatory, but opposite, influences on VS activation. These results link behavioral impulsivity and self-control to dynamically evolving neural representations of future reward value not just during choice, but also post-choice delay periods.