Supratentorial ependymomas: Prognostic factors and outcome analysis in a retrospective series of 46 adult patients
Supratentorial ependymomas: Prognostic factors and outcome analysis in a retrospective series of 46 adult patients
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DOI：
10.1002/cncr.23530
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发表时间：
2008-07-01
期刊：
影响因子：
6.2
通讯作者：
Chinot, Olivier
中科院分区：
文献类型：
--
作者：
Metellus, Philippe;Figarella-Branger, Dominique;Chinot, Olivier
背景室管膜瘤占成人颅内肿瘤的2%。幕上室管膜瘤比幕下室管膜瘤少见。据作者所知，迄今为止，这些肿瘤的手术、组织学和患者相关预后因素的预测价值仍未得到解决。作者报道了一系列幕上室管膜瘤的成人患者，以描述手术和组织学在肿瘤控制中的作用。作者回顾性研究了1990年至2004年间来自法国24家神经外科中心的46例幕上室管膜瘤成人患者。所有的临床放射学和随访数据进行了分析，并进行了中央病理审查由2认证的神经病理学家。整个人群的平均（+/-标准误）5年和10年总生存率分别为57.1%+/-8.7%和41.8%+/-9.9%。整个队列的5年和10年无进展生存率分别为33.8%+/-8.1%和25.4+/-8%。
BACKGROUND. Ependymomas account for 2% of all intracranial tumors in adults. Supratentorial ependymomas are less common than their infratentorial counterparts. To the authors' knowledge to date, the predictive values of surgery, histology, and patient-related prognostic factors for these tumors remain unresolved. The authors report a series of adult patients with supratentorial ependymomas to characterize the roles of surgery and histology in tumor control.METHODS. The authors retrospectively studied a homogenous population of 46 adult patients who had supratentorial ependymomas from 24 French neurosurgical centers between 1990 and 2004. All clinicoradiologic and follow-up data were analyzed, and a central pathologic review was performed by 2 certified neuropathologists.RESULTS. The mean (+/-standard error) 5- and 10-year overall survival races for the entire population were 57.1%+/-8.7% and 41.8%+/-9.9%, respectively. The 5- and 10-year progression-free survival rates for the entire cohort were of 33.8%+/-8.1% and 25.4+/-8%, respectively On both univariate and multivariate analysis, age