Decellularized Extracellular Matrix for Stem Cell Culture
Decellularized Extracellular Matrix for Stem Cell Culture
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DOI：
10.1007/978-981-16-4420-7_17
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
T. Hoshiba
中科院分区：
文献类型：
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作者：
T. Hoshiba
许多脱细胞的细胞外基质已被开发并应用于各种生物工业应用。与这些应用类似，脱细胞的细胞外基质已开始用于干细胞工程。有许多努力来揭示脱细胞化的细胞外基质对干细胞功能的影响，并且已经证明脱细胞化的细胞外基质影响各种干细胞功能，特别是分化、干细胞维持和丧失的干细胞性的恢复（再生）。在这一章中，干细胞功能的脱细胞细胞外基质的来源和脱细胞外基质的制备和表征的描述进行了简要的比较后，总结。此外，本章还概述了脱细胞细胞外基质在干细胞应用中存在的问题。
Many decellularized extracellular matrices have been developed and applied to various bioindustrial applications. Similar to these applications, decellularized extracellular matrices have started to be used for stem cell engineering. There are numerous efforts to unveil the effects of decellularized extracellular matrices on stem cell functions, and it has been demonstrated that decellularized extracellular matrices impact various stem cell functions, particularly differentiation, stem cell maintenance, and recovery of lost stemness (rejuvenation). In this chapter, stem cell functions on the decellularized extracellular matrices are summarized following a brief comparison of sources and a description of decellularized extracellular matrices preparation and characterization. Additionally, the present problems of decellularized extracellular matrices in stem cell applications are outlined in this chapter.