Diagnostic criteria for Parkinson disease
Diagnostic criteria for Parkinson disease
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DOI：
10.1001/archneur.56.1.33
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发表时间：
1999-01-01
影响因子：
--
通讯作者：
Gilman, S
中科院分区：
文献类型：
--
作者：
Gelb, DJ;Oliver, E;Gilman, S
帕金森病（PD）的临床诊断是基于对运动迟缓、强直、震颤和姿势不稳定等主要运动体征的一些组合的识别，但很少有人尝试制定明确的诊断标准。我们提出一个临床诊断分类的基础上，全面检讨文献的敏感性和特异性的特征性临床特征的PD。诊断置信度分为三个级别：确定、可能和可能。可能和可能PD的诊断仅基于临床标准。对于临床诊断为可能或可能PD的患者，需要神经病理学证实才能诊断为明确的PD。组织病理学确认PD的标准也被提出。
The clinical diagnosis of Parkinson disease (PD) is based on the identification of some combination of the cardinal motor signs of bradykinesia, rigidity, tremor, and postural instability, but few attempts have been made to develop explicit diagnostic criteria. We propose a clinical diagnostic classification based on a comprehensive review of the literature regarding the sensitivity and specificity of the characteristic clinical features of PD. Three levels of diagnostic confidence are differentiated: Definite, Probable, and Possible. The diagnoses of Possible and Probable PD are based on clinical criteria alone. Neuropathologic confirmation is required for the diagnosis of Definite PD in patients with the clinical diagnosis of Possible or Probable PD. Criteria for histopathologic confirmation of PD are also presented.