Does the etiology of cardiac amyloidosis determine the myocardial uptake of [18F]-NaF PET/CT?
Does the etiology of cardiac amyloidosis determine the myocardial uptake of [18F]-NaF PET/CT?
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心脏淀粉样变性的病因学是否决定[18F]-NaF PET/CT 的心肌摄取？
DOI：
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发表时间：
2017
影响因子：
2.4
通讯作者：
S. Fanti
中科院分区：
文献类型：
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作者：
C. Gagliardi;E. Tabacchi;R. Bonfiglioli;S. Diodato;C. Nanni;P. Guidalotti;Massimiliano Lorenzini;F. Lodi;A. Milandri;C. Rapezzi;S. Fanti
心脏淀粉样变性(CA)导致不同程度的心肌浸润性病变，最终超声心动图表现为“肥大”。虽然许多非侵入性成像技术(MRI、CT、核素扫描、PET)是有用的，但最终的诊断仍然是基于心肌组织学。我们在两例野生型(ATTRUT)和突变型(ATTRm)Ile68Leu-Transhyretin(TTR)相关CA患者中，探讨了[18F]-NaF PET/CT在本病诊断中的可能作用。
Cardiac amyloidosis (CA) leads to variable degrees of myocardial infiltration with a final echocardiographic phenotype of “hypertrophy.” Although many non-invasive imaging techniques (MRI, CT, scintigraphy, PET) are useful, the definitive diagnosis is still based on myocardial histology. We explored the possible role of [18F]-NaF PET/CT in the diagnosis of this disease in two cases with wild-type (ATTRwt) or mutant (ATTRm) Ile68Leu transthyretin (TTR)-related CA.