EXECUTIVE FUNCTION IN SCHIZOPHRENIA: IS IT LINKED TO PSYCHOSIS AND POOR LIFE FUNCTIONING?
EXECUTIVE FUNCTION IN SCHIZOPHRENIA: IS IT LINKED TO PSYCHOSIS AND POOR LIFE FUNCTIONING?
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DOI：
10.1097/00005053-200211000-00001
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发表时间：
2002-11
期刊：
影响因子：
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通讯作者：
Robyn Reed;M. Harrow;E. Herbener;E. Martin
中科院分区：
文献类型：
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作者：
Robyn Reed;M. Harrow;E. Herbener;E. Martin
作者对参加一项为期 15 年的精神病自然史研究的患者进行了研究，研究了执行功能的主要方面与急性精神病和长期结果的关系。他们在住院 15 年后对 157 名患者进行了评估，其中包括 42 名精神分裂症患者、42 名其他精神病患者和 73 名非精神病患者。患者接受了威斯康星卡片分类测试（WCST）以及精神病和出院后适应的测量。无论精神病如何，精神分裂症患者在 WCST 指数上的表现均显着差于非精神分裂症精神病对照组。精神分裂症患者的执行功能各方面均受到损害，其整体功能和结果水平严重缺陷，而许多整体功能仅中度受损的患者也存在执行功能受损的情况；然而，这些缺陷在整体功能非常差的精神分裂症患者中更为严重。执行功能缺陷似乎是精神分裂症的核心组成部分，而不是急性精神病性紊乱的结果，并且与长期结果相关。
The authors examined the relationship of major aspects of executive function to acute psychosis and long-term outcome in patients enrolled in a 15-year study of the natural history of psychosis. They evaluated 157 patients, including 42 schizophrenic, 42 other psychotic, and 73 nonpsychotic psychiatric patients 15 years after index hospitalization. Patients were administered the Wisconsin Card Sorting Test (WCST) and measures of psychosis and posthospital adjustment. Schizophrenia patients performed significantly worse than both nonschizophrenic psychiatric control groups on WCST indices, regardless of psychosis. Aspects of executive function were impaired in schizophrenia patients with severe deficits in their level of overall functioning and outcome and also in many with only moderate impairment in overall functioning; however, these deficits were seen to a greater degree in schizophrenia patients with very poor overall functioning. Executive function deficits appear to be a core component of schizophrenia rather than an effect of acute psychotic disorganization, and are associated with long-term outcome.