Differentiated embryonic chondrocyte-expressed gene 1 is associated with hypoxia-inducible factor 1α and Ki67 in human gastric cancer.
Differentiated embryonic chondrocyte-expressed gene 1 is associated with hypoxia-inducible factor 1α and Ki67 in human gastric cancer.
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DOI：
10.1186/1746-1596-8-37
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发表时间：
2013-02-27
影响因子：
2.6
通讯作者：
Wang YS
中科院分区：
文献类型：
--
作者：
Jia YF;Xiao DJ;Ma XL;Song YY;Hu R;Kong Y;Zheng Y;Han SY;Hong RL;Wang YS
胃癌是癌症相关死亡的主要原因，但其进展的潜在分子机制在很大程度上是未知的。分化的胚胎软骨细胞表达基因1（DEC 1）是参与肿瘤进展的重要转录因子，并且最近被鉴定为可被缺氧强烈诱导。DEC 1在胃癌细胞内缺氧和增殖信号转导中的作用尚不清楚。采用免疫组化法检测173例胃癌及癌旁组织中DEC 1、缺氧诱导因子1（HIF-1α）和Ki 67的表达。分析DEC 1、HIF-1α和Ki 67之间的关系。DEC 1蛋白在胃癌组织中持续表达于细胞核和细胞质。胃癌组织中DEC 1和HIF-1α蛋白表达率分别为83.8%和54.3%，显著高于癌旁正常组织（83.8% vs23.7%，P <0.001; 54.3% vs12.7%，P< 0.001）。DEC 1和HIF-1α的表达与肿瘤的分化程度有关。（P < 0. 05）。01）。DEC 1水平与HIF-1α水平呈正相关（P < 0. 05）。Ki 67表达（P < 0. 01，r= 0. 290）。01，r=0.249）。DEC 1表达上调可能在胃癌缺氧调节和细胞增殖中起重要作用。相关的分子机制有待进一步研究。本文的虚拟幻灯片可以在这里找到：http://www.diagnosticpathology.diagnomx.eu/vs/1794565980889391med.motic.com/MoticGallery/Slide?网址：http：08d180cd-5fdb-4cee-830a-0b1fef3311f2&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025med.motic.com/MoticGallery/Slide?网址：http：4762991d-3f2f-43aa-b4bf-ecdd2c2ae3ec&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025med.motic.com/MoticGallery/Slide? 2019 - 05 - 22 00：00：00
Gastric cancer is a leading causes of cancer-related deaths ,but the underlying molecular mechanisms of its progression are largely unknown. Differentiated embryonic chondrocyte-expressed gene 1 (DEC1), is an important transcription factor involved in the progression of tumors and has recently been identified to be strongly inducible by hypoxia. Little is known about the contribution of DEC1 to the intracellular hypoxia and proliferation signaling events in gastric cancer. Immunohistochemistry was used to detect the expression of DEC1, hypoxia-inducible factor 1(HIF-1α) and Ki67 in 173 human gastric cancer samples and adjacent non-tumor tissues samples. The relationship between DEC1, HIF-1α and Ki67 was evaluated. DEC1 protein was persistently expressed in the nucleus and cytoplasm of gastric cancer tissue. The protein expression of DEC1 and HIF-1α in tumour tissues was 83.8% and 54.3%, respectively, and was significantly higher than that in adjacent normal tissues (83.8% vs 23.7%, P <0.001; 54.3% vs 12.7%, P< 0.001). The expression of DEC1 and HIF-1α was associated with poor histological differentiation. (P < 0. 01). Furthermore, DEC1 level was positively correlated with HIF-1α (P < 0. 01, r=0.290) and Ki67 expression (P < 0. 01, r=0.249). The upregulation of DEC1 may play an important role in hypoxia regulation and cell proliferation in gastric cancer. The relevant molecular mechanism requires further investigation. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1794565980889391med.motic.com/MoticGallery/Slide?id=08d180cd-5fdb-4cee-830a-0b1fef3311f2&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025med.motic.com/MoticGallery/Slide?id=4762991d-3f2f-43aa-b4bf-ecdd2c2ae3ec&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025med.motic.com/MoticGallery/Slide?id=2717f209-b3fd-4e71-b621-0d60ea507a82&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
4.8
作者：
Li, YX;Xie, MX;Yan, BF
通讯作者：
Yan, BF
影响因子：
10.5
作者：
Boudjelal, M;Taneja, R;Chambon, P
通讯作者：
Chambon, P
DOI：
10.1016/j.bbrc.2010.09.070
发表时间：
2010-10-22
影响因子：
3.1
作者：
Wang, Weibin;Reiser-Erkan, Carolin;Kleeff, Joerg
通讯作者：
Kleeff, Joerg
DOI：
10.1073/pnas.070526297
发表时间：
2000-04-11
影响因子：
11.1
作者：
Sun, H;Taneja, R
通讯作者：
Taneja, R