Optic nerve constraints for carbon ion RT at CNAO - Reporting and relating outcome to European and Japanese RBE
Optic nerve constraints for carbon ion RT at CNAO - Reporting and relating outcome to European and Japanese RBE
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DOI：
10.1016/j.radonc.2019.06.028
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发表时间：
2019-11-01
影响因子：
5.7
通讯作者：
Fossati, Piero
中科院分区：
文献类型：
--
作者：
Dale, Jon Espen;Molinelli, Silvia;Fossati, Piero
背景与目的：到目前为止，碳离子RT （CIRT）对视神经（ON）的剂量限制仅在近红外光谱rbe加权剂量（D-NIRS）中得到验证和报道。本研究的目的是通过分析机构毒性数据并将其与D-NIRS联系起来，改善CNAO的rbe加权剂量（D-LEM）限制。材料与方法：对2013- 2014年38例头颈部CIRT患者共65例on进行分析。复制治疗方案的吸收剂量（D-Abs），随后应用D-LEM和D-NIRS，从而将CNAO的临床毒性与D-NIRS联系起来。结果：中位FU为47（26-67）个月。56个网络的视力得以保留，并尊重旧有的限制。3例on在D-LEM垂直线1% >= 71 Gy(RBE)/D-LEM垂直线20% >= 68 Gy（RBE）出现视力下降，对应D-NIRS垂直线1% >= 68 Gy(RBE)/D-NIRS垂直线20% >= 62 Gy（RBE）。剂量重新计算显示，近红外光谱约束为d -近红外光谱竖条1%
Background and purpose: Until now, carbon ion RT (CIRT) dose constraints for the optic nerve (ON) have only been validated and reported in the NIRS RBE-weighted dose (D-NIRS). The aim of this work is to improve CNAO's RBE-weighted dose (D-LEM) constraints by analyzing institutional toxicity data and by relating it to D-NIRS.Material and methods: A total of 65 ONs from 38 patients treated with CIRT to the head and neck region in the period 2013-14 were analyzed. The absorbed dose (D-Abs) of the treatment plans was reproduced and subsequently both D-LEM and D-NIRS were applied, thus relating CNAO clinical toxicity to D-NIRS.Results: Median FU was 47 (26-67) months. Visual acuity was preserved for the 56 ONs in which the old constraints were respected. Three ONs developed visual decline at D-LEM vertical bar 1% >= 71 Gy(RBE)/D-LEM vertical bar 20% >= 68 Gy (RBE), corresponding to D-NIRS vertical bar 1% >= 68 Gy(RBE)/D-NIRS vertical bar 20% >= 62 Gy(RBE). Dose recalculation revealed that NIRS constraints of D-NIRS vertical bar 1%