Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity
Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity
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DOI：
10.1016/j.neuron.2007.05.028
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发表时间：
2007-06-21
期刊：
影响因子：
16.2
通讯作者：
Huebener, Mark
中科院分区：
文献类型：
--
作者：
Mrsic-Flogel, Thomas D.;Hofer, Sonja B.;Huebener, Mark
依赖经验的可塑性对于发育过程中神经元连接的精确形成至关重要。它通常被认为依赖于Hebbian形式的突触可塑性。此外，神经元还拥有其他自我平衡的方式来补偿感觉输入的变化，但它们在皮质可塑性中的作用尚不清楚。我们使用双光子钙成像来研究动态平衡反应调节是否有助于单眼剥夺(MD)后小鼠视皮层眼特异性反应的改变。短的MD持续时间降低了双眼输入神经元的剥夺眼反应。更长的MD周期增强了睁眼反应，令人惊讶的是，在没有睁眼输入的神经元中，剥夺眼反应也增加了。这些双向反应调节有效地保护了每个神经元的净视觉驱动。我们的发现，在MD之后，剥夺眼睛的反应要么更弱，要么更强，这取决于细胞接受的睁眼输入的量，这证明了在经验依赖的可塑性期间，Hebbian和自稳机制都调节神经元的反应。
Experience-dependent plasticity is crucial for the precise formation of neuronal connections during development. It is generally thought to depend on Hebbian forms of synaptic plasticity. In addition, neurons possess other, homeo-static means of compensating for changes in sensory input, but their role in cortical plasticity is unclear. We used two-photon calcium imaging to investigate whether homeostatic response regulation contributes to changes of eye-specific responsiveness after monocular deprivation (MD) in mouse visual cortex. Short MD durations decreased deprived-eye responses in neurons with binocular input. Longer MD periods strengthened open-eye responses, and surprisingly, also increased deprived-eye responses in neurons devoid of open-eye input. These bidirectional response adjustments effectively preserved the net visual drive for each neuron. Our finding that deprived-eye responses were either weaker or stronger after MD, depending on the amount of open-eye input a cell received, argues for both Hebbian and homeostatic mechanisms regulating neuronal responsiveness during experience-dependent plasticity.