An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis
An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis
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DOI：
10.1016/j.diagmicrobio.2012.06.013
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发表时间：
2012-10-01
影响因子：
2.9
通讯作者：
Roberts, Sally A.
中科院分区：
文献类型：
--
作者：
Williamson, Deborah A.;Basu, Indira;Roberts, Sally A.
最近的报告表明，假阳性的利福平耐药可能是由Xpert MTB/RIF测定确定的。我们使用MTB/RIF法分析了169份标本。以培养为金标准，检测结核分枝杆菌的灵敏度和特异性均为100%。然而，我们发现在4/13（31%）的病例中，该分析错误地分配了利福平耐药性。(C) 2012爱思唯尔公司版权所有。
Recent reports suggest that false-positive rifampicin resistance may be assigned by the Xpert MTB/RIF assay. We analysed 169 specimens using the MTB/RIF assay. Using culture as the gold standard, we found that the assay had 100% sensitivity and specificity for detecting M. tuberculosis. However, we found that the assay incorrectly assigned rifampicin resistance in 4/13 (31%) of cases. (C) 2012 Elsevier Inc. All rights reserved.