Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors
Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors
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DOI：
10.1111/j.0309-0167.2004.01817.x
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发表时间：
2004-03-01
期刊：
影响因子：
6.4
通讯作者：
Sekine, I
中科院分区：
文献类型：
--
作者：
Nakayama, T;Yoshizaki, A;Sekine, I
目的：有强有力的证据表明酪氨酸激酶参与肿瘤进展、细胞生长和分化的调节。近年来报道了多种酪氨酸激酶受体，其中Tie-1和tie - 2是一类重要的受体。血管生成素(Ang)-1是Tie-2酪氨酸激酶受体的配体。本研究的目的是确定Tie-1和2以及Ang-1、2和4在胃腺癌中的表达谱。方法与结果：对89例手术切除的人胃腺癌进行免疫组化研究。其中，60例（67.4%）、61例（68.5%）、69例（77.5%）、75例（84.3%）和47例（52.8%）癌细胞细胞质中Tie-1、2和Ang-1、2、4蛋白染色阳性。Ties和Angs的表达与多种类型的组织学分化和多种临床病理因素有显著相关性。结论：Ties和Angs在人胃腺癌细胞中高表达。这些结果提示，铁ang受体-配体复合物是参与人胃腺癌细胞分化和进展的因素之一。
Aims: There is strong evidence that tyrosine kinases are involved in the regulation of tumour progression, cellular growth and differentiation. Recently, many kinds of tyrosine kinase receptors have been reported, and among them Tie-1 and 2 constitute a major class. Angiopoietin (Ang)-1 is known as a ligand of the Tie-2 tyrosine kinase receptor. The aim of this study was to determine the expression profile of Tie-1 and 2 and Ang-1, 2 and 4 in gastric adenocarcinoma.Methods and results: Eighty-nine cases of surgically resected human gastric adenocarcinoma were studied by immunohistochemistry. Of these, 60 (67.4%), 61 (68.5%), 69 (77.5%), 75 (84.3%), and 47 cases (52.8%) showed positive staining in the cytoplasm of carcinoma cells for the Tie-1 and 2 and Ang-1, 2 and 4 proteins, respectively. The expression of Ties and Angs was significantly correlated with several type of histological differentiation and several clinicopathological factors.Conclusions: Ties and Angs were highly expressed in human gastric adenocarcinoma cells. These findings suggest that the Tie-Ang receptor-ligand complex is one of the factors involved in the cellular differentiation and progression of human gastric adenocarcinoma.