Effects of drinking and smoking on endogenous levels of urinary γ-hydroxybutyric acid, a preliminary study
Effects of drinking and smoking on endogenous levels of urinary γ-hydroxybutyric acid, a preliminary study
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DOI：
10.1016/j.legalmed.2006.05.001
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发表时间：
2006-07-01
期刊：
影响因子：
1.5
通讯作者：
Hashimoto, Yoshiaki
中科院分区：
文献类型：
--
作者：
Moriya, Fumio;Nishimura, Hiroyuki;Hashimoto, Yoshiaki
本研究的目的是确定尿液中γ -羟基丁酸（GHB）的内源性水平是否受到饮酒和吸烟的影响。20名健康志愿者（15名男性，21-45岁；5名女性，22-24岁）的尿液样本。该人群包括4名普通饮酒者（男性），4名普通吸烟者（男性）和12名不吸烟/不饮酒者（7名男性和5名女性）。用气相色谱法测定尿中GHB的含量。尿中内源性GHB水平无性别差异。吸烟男性尿GHB水平为0.52 +/- 0.37 μ g/ml，不吸烟/不饮酒者为0.28 +/- 0.21 μ g/ml，饮酒者为0.23 +/- 0.04 μ g/ml。每组男性的尿GHB水平每天测量三次，连续5天。在吸烟者和非吸烟者/不饮酒者的5天内观察到很大的个体内差异。在此期间，饮酒者的每日内源性GHB水平没有明显变化。我们的初步结果表明，尼古丁对中枢神经系统（CNS）的刺激作用可能导致夜间GHB形成的增加，而乙醇对中枢神经系统的抑制作用可能不影响甚至可能抑制夜间GHB的产生。2006爱思唯尔爱尔兰有限公司版权所有。
The aim of this study was to determine if the endogenous levels of gamma-hydroxybutyric acid (GHB) in urine were affected by drinking and smoking. Urine samples were obtained from 20 healthy volunteers (15 males, 21-45 years; 5 females, 22-24 years). This population included four average drinkers (males), 4 average smokers (males), and 12 nonsmokers/nondrinkers (seven males and five females). Urinary levels of GHB were measured by gas chromatography. No gender differences were observed in the urinary levels of endogenous GHB. The urinary levels of GHB in males were 0.52 +/- 0.37 mu g/ml in smokers, 0.28 +/- 0.21 mu g/ml in nonsmokers/nondrinkers, and 0.23 +/- 0.04 mu g/ml in drinkers. Urinary GHB levels were measured three times a day for 5 consecutive days in a male from each group. Large intra-individual differences were observed over the 5-day period in a smoker and a nonsmoker/nondrinker. No significant changes in daily endogenous GHB levels were observed in a drinker during the period. Our preliminary results suggest that stimulatory effects of nicotine on the central nervous system (CNS) may result in an increase in nocturnal formation of GHB and the depressive effects of ethanol on the CNS may not affect, even may inhibit, nocturnal production of GHB. (c) 2006 Elsevier Ireland Ltd. All rights reserved.