Disseminated cutaneous leishmaniasis due to Leishmania guyanensis:: Case of a patient with 425 lesions
Disseminated cutaneous leishmaniasis due to Leishmania guyanensis:: Case of a patient with 425 lesions
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DOI：
10.4269/ajtmh.2004.71.558
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Pradinaud, R
中科院分区：
文献类型：
--
作者：
Couppié, P;Clyti, E;Pradinaud, R
播散性皮肤利什曼病的特征是在几个解剖部位（头、四肢和躯干）出现大量（大于或等于10个）病变。大多数病变是小的，丘疹，并出现同时或继发于一个或几个局部皮肤利什曼病溃疡病变。我们报告的第一例播散性皮肤利什曼病在法属圭亚那。案件涉及一名24岁的妇女，她的人体免疫缺陷病毒（艾滋病毒）检测呈阴性。该疾病始于三处溃疡病变。1周后，出现多发性丘疹结节样病变。我们共计数了425处病变。病变中观察到利什曼原虫。所涉及的物种为L.圭亚那利什曼病，这是从来没有描述的情况下，播散性皮肤利什曼病。患者经喷他脒一个疗程迅速治愈。播散性皮肤利什曼病应区别于其他类型的利什曼病与多个损害。这些包括无反应性弥漫性皮肤利什曼病、黑热病后利什曼病和与HIV感染相关的利什曼病。
Disseminated cutaneous leishmaniasis is characterized by the presence of a large (greater than or equal to10) number of lesions at several anatomic sites (head, limbs, and trunk). Most of the lesions are small, papular, and appear simultaneously with or secondarily to one or several ulcerated lesions of localized cutaneous leishmaniasis. We report the first case of disseminated cutaneous leishmaniasis in French Guiana. It concerns a 24-year-old woman who tested negative for human immunodeficiency virus (HIV). The disease began with three lesions that became ulcerated. One week later, multiple papulo-nodular lesions appeared. We counted a total of 425 lesions. Leishmania were observed in the lesions. The species involved was L. guyanensis, which has never been described in a case of disseminated cutaneous leishmaniasis. The patient was rapidly cured by a single course of pentamidine. Disseminated cutaneous leishmaniasis should be distinguished from other types of leishmaniasis with multiple lesions. These include anergic diffuse cutaneous leishmaniasis, post-kala-azar leishmaniasis, and leishmaniasis associated with HIV infection.