ON THE QUESTION OF THE PATHOGENETIC IMPORTANCE OF COBALT FOR HARD METAL FIBROSIS OF THE LUNG
ON THE QUESTION OF THE PATHOGENETIC IMPORTANCE OF COBALT FOR HARD METAL FIBROSIS OF THE LUNG
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DOI：
10.1007/bf00432493
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发表时间：
1982-01-01
影响因子：
3
通讯作者：
BRAND, E
中科院分区：
文献类型：
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作者：
HARTUNG, M;SCHALLER, KH;BRAND, E
近年来，在硬质合金磨床中观察到肺纤维化的程度日益增加。这种疾病的原因已被归因于硬金属中所含的钴的影响。本病例涉及一名36岁男性，他暴露于烧结硬质金属部件的研磨粉尘超过10年。肺活检显示晚期活动性肺纤维化。在活检标本钴测定无火焰原子吸收法。与正常对照中测量的值相比，患者的生物样本（尿，7.5 μ g/l;肺，1010 μ g/kg湿重）中的Co含量显著增加。
Pulmonary fibrosis in hard metal grinders has been observed in an increasing degree in recent years. The cause of this disease has been attributed to the influence of the Co contained in hard metals. The present case dealt with a 36-yr-old man who had been exposed to grinding dust from sintered hard metal parts for > 10 yr. Biopsy of the lung revealed an advanced, active pulmonary fibrosis. In the biopsy specimens Co was determined by flameless atomic absorption. The Co content in the biological specimens of the patient (urine, 7.5 .mu.g/l; lung, 1010 .mu.g/kg wet wt) was significantly increased compared with values measured in normal controls.