Demyelination increases radial diffusivity in corpus callosum of mouse brain
Demyelination increases radial diffusivity in corpus callosum of mouse brain
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DOI：
10.1016/j.neuroimage.2005.01.028
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发表时间：
2005-05-15
期刊：
影响因子：
5.7
通讯作者：
Armstrong, RC
中科院分区：
文献类型：
--
作者：
Song, SK;Yoshino, J;Armstrong, RC
如在多发性硬化症（MS）和其他脱髓鞘疾病中所见，髓鞘损伤损害轴突传导，并且也可以与轴突变性相关。对这些疾病的准确评估可能非常有利于评估和选择患者管理的治疗策略。最近，提出了一种检查扩散张量成像（DTI）衍生参数的分析方法来评估轴突损伤、脱髓鞘或两者的程度。目前的研究使用了良好的表征cuprizone模型的实验性脱髓鞘和髓鞘再生的胼胝体在小鼠大脑中，以评估的能力，DTI参数检测髓鞘变性和再生的进展。我们的研究结果表明，径向扩散系数增加的程度反映了受铜腙治疗影响的小鼠脑胼胝体脱髓鞘的严重程度。随后，径向扩散率随着髓鞘再生的进展而降低。此外，径向扩散率的变化是特定的髓鞘完整性的变化的时间过程中，从轴突损伤，这是检测到的DAPP免疫染色和脱髓鞘前显示是最广泛的不同。径向扩散率提供了一个具体的评估脱髓鞘和髓鞘再生，从急性轴突损伤不同。(c)2005年爱思唯尔公司All rights reserved.
Myelin damage, as seen in multiple sclerosis (MS) and other demyelinating diseases, impairs axonal conduction and can also be associated with axonal degeneration. Accurate assessments of these conditions may be highly beneficial in evaluating and selecting therapeutic strategies for patient management. Recently, an analytical approach examining diffusion tensor imaging (DTI) derived parameters has been proposed to assess the extent of axonal damage, demyelination, or both. The current study uses the well-characterized cuprizone model of experimental demyelination and remyelination of corpus callosum in mouse brain to evaluate the ability of DTI parameters to detect the progression of myelin degeneration and regeneration. Our results demonstrate that the extent of increased radial diffusivity reflects the severity of demyelination in corpus callosum of mouse brain affected by cuprizone treatment. Subsequently, radial diffusivity decreases with the progression of remyelination. Furthermore, radial diffusivity changes were specific to the time course of changes in myelin integrity as distinct from axonal injury, which was detected by DAPP immunostaining and shown to be most extensive prior to demyelination. Radial diffusivity offers a specific assessment of demyelination and remyelination, as distinct from acute axonal damage. (c) 2005 Elsevier Inc. All rights reserved.