Simultaneous dual frequency 1H and 19F open coil imaging of arthritic rabbit knee at 3T.
Simultaneous dual frequency 1H and 19F open coil imaging of arthritic rabbit knee at 3T.
复制标题
DOI：
10.1109/tmi.2010.2056689
复制
发表时间：
2011-01
影响因子：
10.6
通讯作者：
Lanza GM
中科院分区：
文献类型：
--
作者：
Hockett FD;Wallace KD;Schmieder AH;Caruthers SD;Pham CT;Wickline SA;Lanza GM
灵敏的磁共振技术与选择性位点靶向纳米颗粒造影剂的组合已被证明可用于分子成像研究。通过检测造影剂的独特特征，该方法可以用于识别特定的生物分子标记物并观察大型复杂生物体内的细胞水平过程（例如，体内兔）。本研究的目的是设计，制造和表征一个射频（RF）线圈的双频（1H和19F）同时收集两个核图像在一个3T的领域，以促进关节炎膝关节退化的研究在兔子。线圈支持发射和接收模式。支持活动包括：1）建立用于计算所需线圈参数的技术数据库，2）选择有利的线圈几何形状，以及3）将现有RF测量技术适用于线圈的设计、开发和电气评价。线圈与Philips Medical Systems临床MRI扫描仪配合使用，要求所有RF同步双频（1H和19F）线圈在发射和接收模式下运行。商业版本的SPICE（模拟程序与集成电路的重点）被用来估计重要的操作参数之前，制造成像线圈。使用制造的线圈获得了极好的图像，并且没有观察到会限制使用其他线圈几何形状和场强的操作问题。
The combination of sensitive magnetic resonance techniques with a selective site-targeted nanoparticle contrast agent has a demonstrated utility for molecular imaging studies. By detecting a unique signature of the contrast agent, this approach can be employed to identify specific bio-molecular markers and observe cellular-level processes within a large and complex organism (e.g., in vivo rabbit). The objective of the present investigation was to design, fabricate and characterize a radio-frequency (RF) coil for the dual frequency (1H and 19F) simultaneous collection of both nuclei images in a 3T field, in order to facilitate studies of arthritic knee degradation in rabbits. The coil supports both transmit and receive modes. The supporting activities included: 1) establishing a technical database for calculating the required coil parameters, 2) selection of a favorable coil geometry, and 3) adaption of existing RF measurement techniques to the design, development and electrical evaluation of the coil. The coil is used in conjunction with a Philips Medical Systems clinical MRI scanner, requiring all RF simultaneous dual frequency (1H and 19F) coils to operate in both transmit and receive modes. A commercial version of SPICE (simulation program with integrated circuit emphasis) was used to estimate significant operational parameters prior to fabricating the imaging coil. Excellent images were obtained with the fabricated coil and no operational problems were observed that would limit the use of other coil geometries and field strengths.