Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives
Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives
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DOI：
10.1016/j.bmcl.2015.01.026
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发表时间：
2015-04-01
影响因子：
2.7
通讯作者：
Akkewar, Dattatray M.
中科院分区：
文献类型：
--
作者：
Konda, Saidulu;Raparthi, Srujana;Akkewar, Dattatray M.
合成了一系列苯并恶嗪-6-磺酰胺衍生物，并对其抗菌活性进行了评价。所有合成的化合物进行了评估，其抗菌和抗真菌活性。其中1a、1b、1c、1 e、1h、2c、2d、2 e、2g、2 h、2 i、2 j、2k和2l对革兰氏阳性菌、革兰氏阴性菌和真菌的抑菌浓度较低（MIC分别为31.25和62.5 μ g/mL），与标准药物的抑菌效果相当。(C)2015爱思唯尔有限公司版权所有。
A new series of benzoxazine-6-sulfonamide derivatives were synthesized in excellent yields and the resulting compounds were evaluated for their antimicrobial activities. All the synthesized compounds were assessed for their antibacterial and antifungal activities. Among them 1a, 1b, 1c, 1e, 1h, 2c, 2d, 2e, 2g, 2h, 2i, 2j, 2k and 2l showed low inhibitory concentration (MIC of 31.25 and 62.5 mu g/mL) against Gram-positive bacteria, Gram-negative bacteria and fungi, which are comparable to the inhibitory effect of standard drugs. (C) 2015 Elsevier Ltd. All rights reserved.