Suppression of human fibrosarcoma cell growth by transcription factor, Egr‐1, involves down‐regulation of Bcl‐2
Suppression of human fibrosarcoma cell growth by transcription factor, Egr‐1, involves down‐regulation of Bcl‐2
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转录因子 Egr-1 抑制人纤维肉瘤细胞生长涉及 Bcl-2 的下调
DOI：
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发表时间：
1998
影响因子：
6.4
通讯作者：
A. Boynton
中科院分区：
文献类型：
--
作者：
R. Huang;Y. Fan;A. Peng;Z. Zeng;John Calvin Reed;E. Adamson;A. Boynton
Previously, we showed that the transcription factor Egr‐1 suppressed the proliferation of v‐sis transformed NIH3T3 cells and also a number of human tumor cells. Here, we investigate the possible mechanisms responsible for this function. We show that transfected Egr‐1 in human fibrosarcoma cells HT1080 leads to down‐regulation of Bcl‐2. Transient CAT transfection assays reveal that expression of Egr‐1 suppresses Bcl‐2 promoter activity in a dose‐dependent manner. Furthermore, overexpression of Bcl‐2 in Egr‐1‐expressing HT1080 cells enhanced cell proliferation in monolayer culture and increased anchorage‐independent growth. Our results suggest that suppression of tumor cell proliferation by Egr‐1 may be at least partially mediated through the down‐regulation of Bcl‐2. Int. J. Cancer 77:880‐886, 1998.© 1998 Wiley‐Liss, Inc.
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影响因子：
11.2
作者：
Abbas Abdollahi;Andrew K. Godwin;P. Miller;Lori A. Getts;David C. Schultz;Takahiro Taguchi;Joseph R
通讯作者：
Abbas Abdollahi;Andrew K. Godwin;P. Miller;Lori A. Getts;David C. Schultz;Takahiro Taguchi;Joseph R
新型初级反应基因 MyD118 和原癌基因 myb、myc 和 bcl-2 调节转化生长因子 β 1 诱导的骨髓性白血病细胞凋亡。
影响因子：
5.3
作者：
Selvakumaran,M;Lin,HK;Sjin,RT;Reed,JC;Liebermann,DA;Hoffman,B
通讯作者：
Hoffman,B
影响因子：
1.5
作者：
Alves, Wellington Forte;Aguiar, Erika Elisa;de Vasconcelos, Paulo Roberto Leitao
通讯作者：
de Vasconcelos, Paulo Roberto Leitao
Bcl-2 抑制 T 细胞介导的白血病细胞系的细胞溶解。
影响因子：
11.2
作者：
Torigoe,T;Millan,JA;Takayama,S;Taichman,R;Miyashita,T;Reed,JC
通讯作者：
Reed,JC
影响因子：
8
作者：
R. Huang;Tristan Darland;D. Okamura;Dan Mercola;Eileen D. Adamson
通讯作者：
R. Huang;Tristan Darland;D. Okamura;Dan Mercola;Eileen D. Adamson