Buspirone and diazepam in anxiety: a controlled study.
Buspirone and diazepam in anxiety: a controlled study.
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丁螺环酮和地西泮治疗焦虑：一项对照研究。
DOI：
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发表时间：
1982
影响因子：
5.3
通讯作者：
J. Danton
中科院分区：
文献类型：
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作者：
K. Rickels;K. Weisman;N. Norstad;M. Singer;D. Stoltz;A. Brown;J. Danton
在一项为期4周的双盲研究中，对240例焦虑患者的丁螺环酮抗焦虑特性进行了评估，其中81例接受丁螺环酮，81例接受地西泮，78例接受安慰剂。要求患者的Covi评分大于或等于9分，汉密尔顿焦虑评定量表评分大于或等于18分，并在17项焦虑条目检查表中至少认可5项。在212名可评估的患者中，改善最多的是已婚、受过良好教育的女性，她们既有积极的家庭适应能力，又有较低的抑郁水平。地西泮在女性和男性中产生相对相等的改善。地西泮似乎更有效地减少躯体症状，而丁螺环酮似乎更有效地减少与认知和人际关系问题有关的症状。药物之间的主要差异是在副作用方面。
The anxiolytic properties of buspirone were assessed in a 4-week double-blind study in 240 anxious patients, 81 of whom received buspirone, 81 diazepam, and 78 placebo. Patients were required to have scores greater than or equal to 9 on the Covi and greater than or equal to 18 on the Hamilton Rating Scale for Anxiety, and to endorse at least 5 items on a 17-item Anxiety Entry Checklist. Among 212 evaluable patients, those who improved most were married, well-educated females who had both a positive family adjustment and a low level of depression. Diazepam produced relatively equal improvement in females and males. Diazepam seems more effective in reducing somatic symptoms, while buspirone appears more effective in reducing symptoms associated with cognitive and interpersonal problems. Main differences between the drugs were seen in side effect profiles.