Cerium(III), Europium(III), and Ytterbium(III) Complexes with Alcohol Donor Groups as Chemical Exchange Saturation Transfer Agents for MRI
Cerium(III), Europium(III), and Ytterbium(III) Complexes with Alcohol Donor Groups as Chemical Exchange Saturation Transfer Agents for MRI
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DOI：
10.1021/ic900696f
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发表时间：
2009-08-03
影响因子：
4.6
通讯作者：
Morrow, Janet R.
中科院分区：
文献类型：
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作者：
Huang, Ching-Hui;Morrow, Janet R.
1，4，7，10-四大环稀土配合物（2-羟乙基）-1，4，7，10-四氮杂环十二烷（THED）和（1S，4S，7S，10S）-1，4，7，10-四研究了（2-羟丙基）-1，4，7，10-四氮杂环十二烷（S-THP）作为化学交换饱和转移（CEST）试剂用于磁共振成像（MRI）应用，这些Ln（III）配合物的四个超精细位移的醇质子在湿d（3）-乙腈中产生单个H-1共振，其与本体水共振（Δ ω）分开8 ppm（Ce）、2 ppm（Nd）、7 ppm（Eu）或17 ppm（Yb）。在低水浓度下，除了Nd（III）外，所有Ln（THED）（3+）或Ln（S-THP）（3+）配合物都观察到对应于醇质子的CEST峰（
Lanthanide(III) complexes of macrocycles 1,4,7,10-tetrakis(2-hydroxyethyl)-1,4,7,10-tetraazacyclododecane (THED) and (1S,4S,7S,10S)-1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane (S-THP) were studied as chemical exchange saturation transfer (CEST) agents for magnetic resonance imaging (MRI) applications, The four hyperfine-shifted alcohol protons of these Ln(III) complexes gave rise to a single H-1 resonance in wet d(3)-acetonitrile that was separated from the bulk water resonance (Delta omega) by 8 ppm (Ce), 2 ppm (Nd), 7 ppm (Eu), or 17 ppm (Yb). A CEST peak corresponding to the alcohol protons was observed for all Ln(THED)(3+) or Ln(S-THP)(3+) complexes except Nd(III) at low water concentrations (