Is optical coherence tomography really a new biomarker candidate in multiple sclerosis? - A structural and functional evaluation
Is optical coherence tomography really a new biomarker candidate in multiple sclerosis? - A structural and functional evaluation
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DOI：
10.1167/iovs.07-0834
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发表时间：
2007-12-01
影响因子：
4.4
通讯作者：
Sobaci, Gungor
中科院分区：
文献类型：
--
作者：
Gundogan, Fatih C.;Demirkaya, Seref;Sobaci, Gungor
目的.评估无视神经炎病史的多发性硬化（MS）患者的结构和功能状态。纳入了39例MS患者，他们在MS诊断之前和之后没有报告任何视觉症状。38名健康受试者作为对照组。视网膜神经纤维层（RNFL）厚度采用光学相干断层扫描仪测定。进行图形视觉诱发电位（PVEP）、全视野视网膜电图（ERG）和多焦视网膜电图（mfERG）检查。MS患者中仅颞侧RNFL厚度显著降低（P = 0.011）。60 min弧形检查（P < 0.001）和15 min弧形检查（P <0.001）的P-100潜伏期显著延迟;然而，仅60 min弧形检查的P-100振幅显著降低（P = 0.026）。MS患者的视杆细胞反应b波隐式时间和标准联合反应a波和b波隐式时间显著延迟。P-100潜伏期延迟的MS患者（21/39; 53.8%）的ERG视锥细胞反应b波振幅显著降低，视锥细胞反应a波和b波隐式时间显著延迟。MS和对照受试者之间以及P-100潜伏期延迟和正常患者之间的mfERG结果没有差异。MS患者RNFL厚度与P-100波幅和潜伏期的Pearson相关性不显著（P > 0.05）。在MS患者中，RNFL厚度和P-100反应之间没有相关性。PVEP似乎是确定无视神经炎病史患者视觉通路受累的更可靠的生物标志物。
PURPOSE. To assess the structural and functional status of patients with multiple sclerosis ( MS) without a history of optic neuritis.METHODS. Thirty-nine patients with MS who had reported no visual symptoms before and after the time of MS diagnosis were included. Thirty-eight healthy subjects were included as a control group. Retinal nerve fiber layer (RNFL) thickness was determined by optical coherence tomography. Pattern visual evoked potentials (PVEP), full-field electroretinogram (ERG), and multifocal electroretinogram (mfERG) were performed.RESULTS. There was a significant reduction (P = 0.011) only in temporal RNFL thickness in patients with MS. P-100 latency was significantly delayed with both 60-min arc checks (P < 0.001) and 15-min arc checks (P < 0.001); however, P-100 amplitude was significantly reduced only in 60-min arc checks ( P = 0.026). Rod response b-wave implicit time and standard combined response a- and b-wave implicit times were significantly delayed in patients with MS. Patients with MS with a delayed P-100 latency (21/39; 53.8%) had significantly reduced cone response b-wave amplitude and significantly delayed cone response a- and b-wave implicit times in ERG. mfERG results did not differ between MS and control subjects and between patients with a delayed and a normal P-100 latency. Pearson correlations between RNFL thickness and P-100 amplitude and latency in patients with MS were not significant (P > 0.05).CONCLUSIONS. There is no correlation between RNFL thickness and P-100 response in patients with MS. PVEP seems to be a more reliable biomarker in determining visual pathway involvement in patients with no history of optic neuritis.