Isolation of a new potent cytotoxic pigment along with indigotin from the pathogenic basidiomycetous fungus Schizophyllum commune
Isolation of a new potent cytotoxic pigment along with indigotin from the pathogenic basidiomycetous fungus Schizophyllum commune
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DOI：
10.1023/a:1007082619328
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发表时间：
1999-01-01
期刊：
影响因子：
5.5
通讯作者：
Kawai, K
中科院分区：
文献类型：
--
作者：
Hosoe, T;Nozawa, K;Kawai, K
从一例人类过敏性支气管炎患者的支气管壁分离出裂殖酵母的液体培养基中，分离出吲哚类化合物，裂殖菌素，以及吲哚(靛蓝)、靛玉红、靛红和色氰菊酯。通过波谱分析确定了五味子甲素的结构。裂殖素对小鼠淋巴瘤细胞有较强的细胞毒作用。文中还列出了该化合物的H-1-和C-13-核磁共振信号归属。
An indole derivative, schizocommunin, was isolated along with indigotin (indigo), indirubin, isatin, and tryptanthrin, from the liquid culture medium in which a culture of Schizophyllum commune, isolated from the bronchus of a human patient with allergic bronchopulmonary mycosis, had been grown. The structure of schizocommunin was established by spectroscopic investigation. Schizocommunin showed the strong cytotoxicity against murine lymphoma cells. The assignments of the H-1- and C-13-NMR signals of indigotin were also listed.