Postmortem studies of the hippocampal formation in schizophrenia
Postmortem studies of the hippocampal formation in schizophrenia
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DOI：
10.1093/schbul/23.3.385
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发表时间：
1997-01-01
影响因子：
6.6
通讯作者：
Dwork, AJ
中科院分区：
文献类型：
--
作者：
Dwork, AJ
许多尸检研究报道了精神分裂症患者和对照组海马结构的差异，这些差异包括体积变化、细胞密度变化、脑室周围胶质增生、老年退行性变化以及神经元大小、位置或方向的异常。此外，一些精心设计的研究是负面的，不同的积极报告是相互矛盾的，一些不一致的方法，正常的变化，在小的距离，在颞叶皮层的细胞结构造成特别困难时，这一地区的研究与有限数量的切片，特别是如果样本量小，其他不一致的结果可能是病例选择。我们回顾了其中一些研究的方法和发现，强调消除（而不是评估）具有明确神经病理变化的病例的危险，我们得出的结论是，现有的颞叶形态学尸检研究几乎没有为精神分裂症的神经基质提供确凿的证据。
Many postmortem studies report differences between the hippocampal formations of patients with schizophrenia and those of controls, These differences include volume changes, cell density changes, periventricular gliosis, senile degenerative changes, and abnormalities of neuronal size, position, or orientation, However, the findings are almost never common to all schizophrenia patients within a series. Furthermore, some well-designed studies are negative, and different positive reports are mutually contradictory, Some of the inconsistencies are methodological, The normal variation, over small distances, in the cytoarchitecture of the temporal allocortex creates particular difficulties when this region is studied with a limited number of sections, especially if the sample size is small, Other inconsistencies are probably the result of case selection. We review the methods and findings of some of these studies, stressing the dangers of eliminating (rather than evaluating) cases with definite neuropathologic changes, We conclude that the existing postmortem studies of temporal lobe morphology provide little conclusive evidence for the neural substrate of schizophrenia.