The self-assembly of a camptothecin-lysine nanotube
The self-assembly of a camptothecin-lysine nanotube
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DOI：
10.1016/j.bmcl.2016.04.056
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发表时间：
2016-06-15
影响因子：
2.7
通讯作者：
Parquette, Jon R.
中科院分区：
文献类型：
--
作者：
Sun, Yuan;Shieh, Aileen;Parquette, Jon R.
据报道，一种简单的低分子量喜树碱-赖氨酸缀合物可自组装成直径为70-100纳米的纳米管，载药量为60.5%。该纳米管在体外对癌细胞系A549、NCI-H460和NCI-H23表现出良好的细胞毒性。活性喜树碱的释放高度依赖于结合物浓度、温度和溶液的pH。(C)2016爱思唯尔有限公司版权所有
A simple, low molecular weight camptothecin-lysine conjugate is reported to self-assemble into nanotubes with diameters of 70-100 nm and a drug loading level of 60.5%. The nanotubes exhibited promising in vitro cytotoxicity against cancer cell lines A549, NCI-H460 and NCI-H23. The release of active camptothecin was highly dependent on conjugate concentration, temperature and pH of the solution. (C) 2016 Elsevier Ltd. All rights reserved.