Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer
Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer
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DOI：
10.1160/th06-03-0141
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发表时间：
2007-01-01
影响因子：
6.7
通讯作者：
Weltermann, Ansgar
中科院分区：
文献类型：
--
作者：
Hron, Gregor;Kollars, Marietta;Weltermann, Ansgar
癌症中高凝状态的发病机制尚不完全清楚。我们假设，在癌症患者中，循环组织因子阳性微粒(Tf+MPS)增加，并与止血系统激活有关。用流式细胞仪检测了20例晚期结直肠癌患者和20例年龄、性别匹配的正常对照血浆中Tf+MPS的数量和细胞来源。D-二聚体被确定为止血系统激活的指标。与对照组相比，癌症患者Tf+MPS的中位数(四分位数范围)增加了一倍：25.9x10(3)/ml血浆比13.1x10(3)/ml血浆，p=0.007。这主要是由于来自血小板的Tf+MPS较高(13.4x10(3)/ml血浆vs.5.8[4.57.5]x10(3)/ml血浆，p=0.017)。Tf+MPS与D-二聚体相关(p=0.48，p=0.002)。肿瘤患者高水平的Tf+MPS及其与D-C lener的相关性提示Tf+MPS可能参与了肿瘤患者的止血激活。
The pathogenesis of hypercoagulability in cancer is not entirely understood. We hypothesized that in cancer patients circulating tissue factor-positive microparticles (TF+ MPs) are increased and associated with hemostatic system activation. In 20 patients with advanced colorectal cancer and in 20 age- and sex-matched controls, number and cellular origin of TF+ MPs were determined in plasma by flow cytometry. D-dimer was determined as an indicator of hemostatic system activation. Compared to controls, the median (interquartile range) number of TF+ MPs was two-fold higher in cancer patients: 25.9 (15.4 - 42.0) x 10(3)/ml plasma versus 13.1 (11.9 - 19.7) x 10(3)/ml plasma, p = 0.007. This was mainly due to a higher amount of TF+ MPs from platelets (13.4 [5.0 - 17.4] x 10(3)/ml plasma vs. 5.8 [4.5 - 7.5] x 10(3)/ml plasma, p = 0.017). TF+ MPs correlated with D-dimer (p = 0.48, p = 0.002). High levels of TF+ MPs in cancer patients and their correlation with D-climer suggest that TF+ MPs might be involved in hemostasis activation in cancer patients.