Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort.
Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort.
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DOI：
10.1017/s0954579414000649
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发表时间：
2015-03
影响因子：
3.3
通讯作者：
Johnson KC
中科院分区：
文献类型：
--
作者：
Smearman EL;Winiarski DA;Brennan PA;Najman J;Johnson KC
在现有文献中，催产素受体基因(OXTR)的多态性通常与亲社会行为有关，但很少有人研究它们在反社会行为中的作用，特别是在青春期到成年早期的转变过程中。我们调查了一个前瞻性队列(N=404)，收集了15岁和20岁的青少年、母亲和临床医生关于行为紊乱和反社会行为的报告。催产素受体rs53576基因多态被假设为与社会压力相互作用，以预测反社会结果。结构方程模型(SEM)结果显示，15岁时有显著的主效应(p=.025)；携带G等位基因的人表现出更高水平的品行问题。扫描电子显微镜显示，在20岁时，基因与环境之间存在显著的交互作用(p=.029)；携带G等位基因的人在经历高社会压力时表现出更高的反社会行为水平。比较了杂合子(AG)分组模型，参数估计支持G显性分组。这些新的发现表明，rs53576基因多态可能会影响社会显着性，并导致反社会结果的风险，特别是在高社会压力的条件下。
Polymorphisms in the oxytocin receptor gene (OXTR) are commonly associated with prosocial behaviors in the extant literature, yet their role in antisocial behaviors has rarely been explored, particularly during the transition from adolescence to early adulthood. We examined a prospective cohort (N=404), collecting youth, mother and clinician reports of conduct disordered and antisocial behavior at age 15 and 20. The oxytocin receptor rs53576 polymorphism was hypothesized to interact with social stress to predict antisocial outcomes. Structural equation modeling (SEM) results revealed a significant main effect at age 15 (p=.025); those with the G allele exhibited higher levels of conduct problems. SEM revealed a significant gene-by-environment interaction at age 20 (p=.029); those with the G allele who experienced high social stress exhibited higher levels of antisocial behavior. Heterozygous (AG) grouping models were compared and parameter estimations supported G dominant groupings. These novel findings suggest that rs53576 polymorphisms may influence social salience and contribute to risk for antisocial outcomes, particularly under conditions of high social stress.