A Common Integrative Nuclear Signaling Module for Stem Cell Development
A Common Integrative Nuclear Signaling Module for Stem Cell Development
复制标题
用于干细胞发育的通用整合核信号模块
DOI：
10.1142/9789814317931_0004
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
E. Tzanakakis
中科院分区：
文献类型：
--
作者：
M. Stachowiak;E. Stachowiak;J. M. Aletta;E. Tzanakakis
个体发育需要多个基因程序通过大量的细胞外和细胞内信号的协调调节。作为基因调控的结果，干细胞在自我更新和分化状态之间交替。这种调节的破坏可能导致致癌转化，其中干细胞在增殖状态下被“阻止”。系统生物学的新兴原理表明，计算网络模块负责整合决定特定发育阶段的表观遗传信号。已经鉴定了控制进入细胞周期和促进干细胞永久自我更新的模块。在这一章中，我们总结了目前的理解一种新的前馈与门网络模块，影响干细胞和神经祖细胞的分化。在这个模块的中心是新的基因控制机制-整合核成纤维细胞生长因子受体（FGFR）-1信号转导（INFS）。INFS的增强可用于重建协调的基因调控以激活细胞分化用于再生目的或提供癌症干细胞增殖的中断。
Ontogeny requires the coordinated regulation of multi-gene programs by a plethora of extracellular and intracellular signals. As a result of gene regulation, stem cells alternate between states of self-renewal and differentiation. Disruption of this regulation may cause oncogenic transformation in which stem cells are “arrested” in the proliferative state. The emerging principles of systems biology suggest that computational network modules are responsible for the integration of epigenetic signals that determine specific developmental stages. Modules that control entry into cell cycle and promote perpetual self-renewal of the stem cells have been identified. In this chapter, we summarize the current understanding of a novel Feed-Forward-And-Gate network module that affects the differentiation of stem cells and neural progenitor cells. In the center of this module is the new gene controlling mechanism — integrative nuclear fibroblast growth factor receptor (FGFR)-1 signaling (INFS). Enhancement of the INFS may be used to reestablish coordinated gene regulation to activate cell differentiation for regenerative purposes or to provide interruption of cancer stem cell proliferation.