Glycaemia-independent ethnic differences in HbA1c in subjects with impaired glucose tolerance
Glycaemia-independent ethnic differences in HbA1c in subjects with impaired glucose tolerance
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DOI：
10.1111/j.1464-5491.2009.02803.x
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发表时间：
2009-10-01
影响因子：
3.5
通讯作者：
Gama, R.
中科院分区：
文献类型：
--
作者：
Likhari, T.;Gama, R.
目的 研究糖耐量受损的白人和南亚人之间 HbA(1c) 的种族差异。方法我们审核了在伍尔弗汉普顿新十字医院临床化学部门进行的 75 克口服葡萄糖耐量试验 (OGTT)，历时一年多。比较了白人和糖耐量异常 (IGT) 南亚人之间的 HbA(1c) 和血糖。结果 共有 46 名南亚人（22 名女性）和 88 名白人（41 名女性）。与白人受试者相比，南亚受试者更年轻（59.2 +/- 14.31 对比 67.6 +/- 12.63 岁；P < 0.001），体重更轻（78.1 +/- 17.2 对比 87.47 +/- 19.1 公斤；P < 0.001）。与白人相比，南亚人的 HbA(1c) 水平较高（6.5 +/- 0.7 vs. 6.1 +/- 0.6%；P < 0.001）。南亚人的空腹血糖（5.71 +/- 0.5 对比 5.93 +/- 0.7；P = 0.039）较低，但两个种族的 2 小时血糖（10.5 +/- 1.0 对比 10.40 +/- 0.9；P = 0.404）相似。结论 尽管南亚人的空腹血糖值较低，但南亚人的 HbA(1c) 水平高于白人。 OGTT，表明种族差异 HbA(1c) 中的糖化血红蛋白 (HbA1c) 是由与血糖无关的因素引起的。
AimTo study the ethnic differences in HbA(1c) between Whites and South Asians with impaired glucose tolerance.MethodsWe audited 75g oral glucose tolerance tests (OGTT) performed in Clinical Chemistry, New Cross Hospital, Wolverhampton over 1 year. HbA(1c) and glycaemia were compared between Whites and South Asians with impaired glucose intolerance (IGT).ResultsThere were 46 South Asians (22 female) and 88 Whites (41 female). South Asian subjects were younger (59.2 +/- 14.31 vs. 67.6 +/- 12.63 yrs; P < 0.001) and weighed less (78.1 +/- 17.2 vs. 87.47 +/- 19.1 kgs; P < 0.001) than White subjects. HbA(1c) levels were higher (6.5 +/- 0.7 vs. 6.1 +/- 0.6%; P < 0.001) in South Asians compared to Whites. Fasting glucose (5.71 +/- 0.5 vs. 5.93 +/- 0.7; P = 0.039) was lower in South Asians but 2hour glucose (10.5 +/- 1.0 vs. 10.40 +/- 0.9; P = 0.404) was similar in both ethnic groups.ConclusionSouth Asians have higher HbA(1c) levels than Whites despite lower fasting glucose value on OGTT, indicating ethnic differences in HbA(1c) are due to glycaemia-independent factors.