Opinion - Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
Opinion - Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
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DOI：
10.1038/nri1807
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发表时间：
2006-04-01
影响因子：
100.3
通讯作者：
Dong, C
中科院分区：
文献类型：
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作者：
Dong, C
长期以来，CD 4（+）T辅助细胞1（T（H）1）和T（H）2细胞被认为是适应性免疫反应的硬币的两面。然而，正如我在这里讨论的，这个概念需要重新考虑。特别是，最近的数据表明，白细胞介素-17（IL-17）是由不同于传统T（H）1-和T（H）2-细胞亚群的T-H细胞产生的。此外，在免疫应答期间，这些产生IL-17的CD 4（+）T细胞从幼稚前体产生，并不依赖于介导T（H）1-和T（H）2-细胞发育的细胞因子和转录因子。鉴于IL-17在几种自身免疫动物模型中调节组织炎症和疾病发展方面具有关键作用，我认为产生IL-17的CD 4（+）T细胞代表了一种独特的炎性T-H细胞谱系。
CD4(+) T helper 1 (T(H)1) and T(H)2 cells have long been regarded as two sides of a coin in terms of adaptive immune responses. However, as I discuss here, this concept needs to be reconsidered. In particular, recent data indicate that interleukin-17 (IL-17) is produced by T-H cells that are distinct from the traditional T(H)1- and T(H)2-cell subsets. Furthermore, the generation of these IL-17-producing CD4(+) T cells from naive precursors during immune responses is not dependent on the cytokines and transcription factors that mediate T(H)1- and T(H)2-cell development. Given that IL-17 has crucial roles in regulating tissue inflammation and the development of disease in several animal models of autoimmunity, I propose that IL-17-producing CD4(+) T cells represent a distinct inflammatory T-H-cell lineage.