THE DUAL EFFECT OF MEMBRANE POTENTIAL ON SODIUM CONDUCTANCE IN THE GIANT AXON OF LOLIGO
THE DUAL EFFECT OF MEMBRANE POTENTIAL ON SODIUM CONDUCTANCE IN THE GIANT AXON OF LOLIGO
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DOI：
10.1113/jphysiol.1952.sp004719
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发表时间：
1952-01-01
影响因子：
5.5
通讯作者：
HUXLEY, AF
中科院分区：
文献类型：
--
作者：
HODGKIN, AL;HUXLEY, AF
结果膜电位的微小变化对膜钠渗透性增加的能力的影响如图1所示。在该实验中，膜电位分两步改变。第一步的幅度为-8 mV。其持续时间在 O 到 50 毫秒之间变化。此步骤称为调节电压 (V1)。接下来是称为测试电压 (V2) 的第二步，该电压保持在 44 mV 的恒定幅度。记录 A 给出了仅使用测试电压观察到的电流。 BF 显示了在此之前通过不同持续时间的调节脉冲的效果。虽然去极化为8 mV。与任何明显的内向电流无关，它极大地改变了神经的后续反应。因此，如果调节电压持续时间超过 20 毫秒，就会减少内向电压。
RESULTSThe influence of a small change in membrane potential on the ability of the membrane to undergo its increase in sodium permeability is illustrated by Fig. 1. In this experiment the membrane potential was changed in two steps. The amplitude of the first stepwas-8 mV. and its duration varied between O and 50 msec. This step will be called the conditioning voltage (V1). It was followed by a second step called the test voltage (V2) which was kept at a con-stant amplitude of-44 mV.Record A gives the current observed with the test voltage alone. BF show the effect of preceding this by a conditioning pulse of varying duration. Although the depolarization of8 mV. was not associated with any appreciable inward current it greatly altered the subsequent response of the nerve. Thus, if theconditioning voltage lasted longer than 20 msec., it reduced the inward