Increased serum ghrelin in preeclampsia: Is ghrelin a friend or a foe?
Increased serum ghrelin in preeclampsia: Is ghrelin a friend or a foe?
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DOI：
10.17772/gp/57852
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发表时间：
2016-01-01
影响因子：
1.3
通讯作者：
Yilmaz, Necat
中科院分区：
文献类型：
--
作者：
Erol, Onur;Ellidag, Hamit Y.;Yilmaz, Necat
目的：为探讨妊娠合并子痫前期孕妇血清ghrelin水平与疾病严重程度的关系，采用病例对照研究方法，对40例健康孕妇、42例轻度子痫前期患者和40例重度子痫前期患者进行了血清ghrelin水平的检测。两组在母亲、胎龄和体重指数方面相匹配。结果：轻、重度子痫前期患者血清ghrelin水平均显著高于正常对照组（p0.05）。在对照组中，没有观察到ghrelin水平与任何其他参数之间的显著相关性，但在先兆子痫组中，血清ghrelin水平与子宫动脉多普勒指数值以及收缩压和舒张压均呈负相关（均为p值
Objectives: To investigate maternal serum ghrelin levels in pregnancies complicated by preeclampsia and to explore the relationship between ghrelin level and disease severity.Materials and methods: This case control study included 40 healthy pregnant women, 42 women with mild preeclampsia, and 40 women with severe preeclampsia. The groups were matched in terms of maternal and gestational age and body mass index. Serum ghrelin levels were measured via enzyme immunoassay.Results: Serum ghrelin levels were significantly higher in women with mild and severe preeclampsia than in healthy controls (p0.05). In the control group, no significant correlation was observed between ghrelin level and any other parameter, but in the preeclampsia group, serum ghrelin levels were negatively correlated with uterine artery Doppler index values and both systolic and diastolic blood pressure (all p-values