Superferromagnetic Nanoparticles Enable Order-of-Magnitude Resolution & Sensitivity Gain in Magnetic Particle Imaging.
Superferromagnetic Nanoparticles Enable Order-of-Magnitude Resolution & Sensitivity Gain in Magnetic Particle Imaging.
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DOI：
10.1002/smtd.202100796
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发表时间：
2021-11
期刊：
影响因子：
12.4
通讯作者：
Conolly SM
中科院分区：
文献类型：
--
作者：
Tay ZW;Savliwala S;Hensley DW;Fung KLB;Colson C;Fellows BD;Zhou X;Huynh Q;Lu Y;Zheng B;Chandrasekharan P;Rivera-Jimenez SM;Rinaldi-Ramos CM;Conolly SM
磁性纳米颗粒在医学上有许多优点，例如它们在非侵入性成像中用作磁颗粒成像（MPI）示踪剂或磁共振成像造影剂，能够被外部移动或驱动，并被外部激发以产生热量或释放治疗药物。现有的纳米颗粒具有温和的s形磁化响应，限制了分辨率和灵敏度。本研究表明，超铁磁氧化铁纳米颗粒链（SFMIOs）实现了理想的步进式磁化响应，将图像分辨率和信噪比提高了10倍以上。潜在的机制依赖于响应于20 kHz， 15 kAm−1 MPI激励的方形磁滞环的动态磁化，纳米颗粒在外加磁场下组装成链。实验数据表明，当施加的电场超过链中相邻纳米粒子的偶极子-偶极子场的动态矫顽力阈值时，链中每个纳米粒子都会发生“一维雪崩”偶极子反转。该事件产生强烈的感应信号，导致信号尖峰。我们展示了新颖的MPI成像策略，以利用这种行为进行数量级的医学图像改进。sfmio可以为癌症、肺栓塞、胃肠道出血、中风和炎症成像的无创成像提供突破。磁颗粒成像是一种不同于核磁共振成像的新型成像方法，它可以对磁性纳米颗粒进行示踪成像。这项工作展示了如何利用线性氧化铁纳米颗粒链（SFMIOs）中的超铁磁性将MPI图像的空间分辨率和灵敏度提高10倍。SFMIO可能使癌症、血管和干细胞成像更加敏感和准确。
Magnetic nanoparticles have many advantages in medicine such as their use in non-invasive imaging as a Magnetic Particle Imaging (MPI) tracer or Magnetic Resonance Imaging contrast agent, the ability to be externally shifted or actuated and externally excited to generate heat or release drugs for therapy. Existing nanoparticles have a gentle sigmoidal magnetization response that limits resolution and sensitivity. Here we show that superferromagnetic iron oxide nanoparticle chains (SFMIOs) achieve an ideal step-like magnetization response to improve both image resolution & SNR by more than 10-fold over conventional MPI. The underlying mechanism relies on dynamic magnetization with square-like hysteresis loops in response to 20 kHz, 15 kAm−1 MPI excitation, with nanoparticles assembling into a chain under an applied magnetic field. Experimental data shows a ‘1D avalanche’ dipole reversal of every nanoparticle in the chain when the applied field overcomes the dynamic coercive threshold of dipole-dipole fields from adjacent nanoparticles in the chain. Intense inductive signal is produced from this event resulting in a sharp signal peak. We demonstrate novel MPI imaging strategies to harness this behavior towards order-of-magnitude medical image improvements. SFMIOs could provide a breakthrough in noninvasive imaging of cancer, pulmonary embolism, gastrointestinal bleeds, stroke, and inflammation imaging. Magnetic Particle Imaging is a new imaging method different from MRI that enables tracer-like imaging of magnetic nanoparticles. This work demonstrates how superferromagnetism in a linear chain of iron oxide nanoparticles (SFMIOs) can be harnessed to improve MPI image spatial resolution and sensitivity 10-fold. SFMIO potentially enables more sensitive and accurate cancer, vascular and stem cell imaging.
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影响因子：
4.6
作者：
Fu R;Yan Y;Roberts C;Liu Z;Chen Y
通讯作者：
Chen Y
影响因子：
3.8
作者：
Deissler, Robert J.;Wu, Yong;Martens, Michael A.
通讯作者：
Martens, Michael A.
影响因子：
3.7
作者：
Rahmer J;Stehning C;Gleich B
通讯作者：
Gleich B
影响因子：
3.2
作者：
Ferguson, R. Matthew;Khandhar, Amit P.;Krishnan, Kannan M.
通讯作者：
Krishnan, Kannan M.
DOI：
10.1002/pssa.2210110117
发表时间：
1972-01-01
影响因子：
2
作者：
BOSTANJOGLO, O;ROHKEL, K
通讯作者：
ROHKEL, K