Phase-locking of hippocampal interneurons' membrane potential to neocortical up-down states
Phase-locking of hippocampal interneurons' membrane potential to neocortical up-down states
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DOI：
10.1038/nn1788
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发表时间：
2006-11-01
影响因子：
25
通讯作者：
Mehta, Mayank R.
中科院分区：
文献类型：
--
作者：
Hahn, Thomas T. G.;Sakmann, Bert;Mehta, Mayank R.
在安静清醒、睡眠和麻醉状态下，新皮质锥体神经元的膜电位呈现同步的、缓慢的振荡，即所谓的上下状态（UDS），这种振荡可以在局部场电位（LFP）中检测到。这种同步、自发的新皮层活动对海马体的影响在很大程度上是未知的。我们对海马背侧CA1中间神经元进行了第一次体内全细胞记录，发现它们的膜电位在小延迟的情况下被锁相到新皮层的上下状态。这些结果为皮质-海马相互作用提供了强有力的证据，并表明在UDS期间，新皮质活动驱动海马中间神经元。
During quiet wakefulness and sleep, and under anesthesia, the membrane potentials of neocortical pyramidal neurons show synchronous, slow oscillations, so-called up-down states ( UDS), that can be detected in the local field potential ( LFP). The influence of this synchronized, spontaneous neocortical activity on the hippocampus is largely unknown. We performed the first in vivo whole-cell recordings from hippocampal dorsal CA1 interneurons and found that their membrane potentials were phase-locked to neocortical up- down states with a small delay. These results provide strong evidence for cortico-hippocampal interaction and suggest that neocortical activity drives hippocampal interneurons during UDS.