FERRITIN IS A COMPONENT OF THE NEURITIC (SENILE) PLAQUE IN ALZHEIMER DEMENTIA
FERRITIN IS A COMPONENT OF THE NEURITIC (SENILE) PLAQUE IN ALZHEIMER DEMENTIA
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DOI：
10.1007/bf00334497
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发表时间：
1990-01-01
影响因子：
12.7
通讯作者：
JOSHI, JG
中科院分区：
文献类型：
--
作者：
GRUNDKEIQBAL, I;FLEMING, J;JOSHI, JG
在阿尔茨海默病海马的神经（老年性）斑块中观察到对铁蛋白的强免疫反应性。铁蛋白的积累几乎完全与小胶质细胞有关，小胶质细胞似乎有很大的增殖。这些细胞也呈HLA-DR阳性，这是一种推定的反应性小胶质细胞的标记物。相反，在弥漫性斑块中，没有神经炎病理，铁蛋白染色的小胶质细胞似乎是正常的。小胶质细胞经常与发生神经原纤维变化的神经元接触，但只有细胞外空间的缠结呈铁蛋白阳性。Western blots在从阿尔茨海默氏症患者的大脑中分离的成对螺旋细丝中没有检测到铁蛋白，这表明铁蛋白很可能与这些原纤维弱相关，而不是这些原纤维的组成部分。铁蛋白/小胶质细胞活性增加与血脑屏障渗漏没有相关性。铁蛋白，一种储存铁的蛋白质，可能在淀粉样蛋白的形成中起作用，通过铁蛋白分子释放铁时产生的自由基的作用。或者，铁蛋白/小胶质细胞系统可能是次要参与淀粉样蛋白的去除和加工。
A strong immunoreactivity for ferritin was observed in the neuritic (senile) plaques in Alzheimer's disease hippocampus. The ferritin accumulation was almost exclusively associated with the microglia, which appeared to have proliferated greatly. These cells were also positive for HLA-DR, a putative marker for reactive microglia. In contrast, in the diffuse plaques, which were without neuritic pathology, the ferritin-stained microglia appeared to be normal. Microglia were seen frequently in contact with neurons undergoing neurofibrillary changes but only the tangles in the extracellular space were ferritin positive. No ferritin was detected, by Western blots, in paired helical filaments isolated from Alzheimer's disease brain, suggesting that ferritin was most likely weakly associated with and was not a constituent of these fibrils. No correlation between increased ferritin/microglia activity and blood-brain barrier leakage was detected. Ferritin, an iron-storage protein, might have a role in the formation of amyloid through the action of free radicals generated during the release of iron from the ferritin molecule. Alternatively, the ferritin/microglia system might be secondarily involved in the removal and processing of the amyloid.