Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study
Antiplatelet effect of 50-mg maintenance dose of clopidogrel compared to 200 mg ticlopidine: a preliminary study
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50 mg 维持剂量氯吡格雷与 200 mg 噻氯匹定相比的抗血小板作用：初步研究
DOI：
10.1007/s00380-009-1165-y
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发表时间：
2010
影响因子：
1.5
通讯作者：
I. Komuro
中科院分区：
文献类型：
--
作者：
K. Fukushima;Yoshio Kobayashi;H. Kitahara;Y. Iwata;N. Kuroda;Masayuki Ooyama;Y. Kuwabara;F. Nomura;I. Komuro
在美国和欧洲，冠状动脉支架患者服用75毫克氯吡格雷。由于在日本，冠状动脉支架患者的维持剂量为100毫克，每天两次，在美国和欧洲，250毫克，在日本患者中，较低剂量的氯吡格雷可能达到与200毫克噻氯匹定相当的抗血小板作用。104例连续服用50 mg氯吡格雷加阿司匹林(n=54)和200 mg替氯匹定加阿司匹林(n=50)的患者进行了血小板聚集试验。用二磷酸腺苷(5和20μ/L)刺激血小板，用光学聚集法测定聚集功能。氯吡格雷5 0 mg和替氯匹定2 0 0 mg诱导的血小板聚集率分别为37%±11%和38%±15%(P<0.0 5)，2 0μ摩尔/L二磷酸腺苷诱导的血小板聚集率分别为48%±13%和51%±12%(P<0.0 5)。在日本患者中，维持剂量为50毫克的氯吡格雷对血小板的抑制作用可能与200毫克的噻氯匹定相当。
In the United States and Europe, patients with coronary stents are maintained on 75 mg clopidogrel. Because the maintenance dose of ticlopidine in patients with coronary stents is 100 mg twice daily in Japan and 250 mg twice daily in the United States and Europe, in Japanese patients a lower dose of clopidogrel may achieve an antiplatelet effect comparable to 200 mg ticlopidine. Platelet aggregation was evaluated in 104 consecutive patients on 50 mg clopidogrel plus aspirin (n= 54) and 200 mg ticlopidine plus aspirin (n= 50). Platelets were stimulated with adenosine diphosphate (5 and 20 μmol/l) and aggregation was assessed by optical aggregometry. There was no significant difference in platelet aggregation induced with 5 (37% ± 11% vs 38% ± 15%, not significant) and 20 μmol/l adenosine diphosphate (48% ± 13% vs 51% ± 12%, not significant) between 50 mg clopidogrel and 200 mg ticlopidine. In Japanese patients, there is the possibility that a maintenance dose of 50 mg clopidogrel on platelet inhibition is comparable to 200 mg ticlopidine.
冠状动脉和全身循环中冯维勒布兰德因子蛋白的增加超过 ADAMTS13 活性证明急性心肌梗死是一种全身性血栓前病症（同行评审）
DOI：
--
发表时间：
2008
期刊：
Heart and Vessels (掲載確定)
影响因子：
--
作者：
Horii M;Uemura S;Uemura M;Matsumoto m;Ishizashi H;Imagawa K;Iwama H;Takeda Y;Kawata H;Nakajima T;Fujimura y;Saito Y.
通讯作者：
Saito Y.