Mitochondrial dynamics in adaptive and maladaptive cellular stress responses.

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses.
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DOI:
10.1038/s41556-018-0133-0
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发表时间:
2018-07
影响因子:
21.3
通讯作者:
Hajnóczky G
Hajnóczky G
中科院分区:
生物学1区
文献类型:
--
作者:
Eisner V;Picard M;Hajnóczky G

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线粒体感知并响应许多应激源,并可以通过能量产生和信号传导途径支持细胞存活或死亡。线粒体的反应依赖于稀释和分离受损线粒体的融合-裂变动力学。线粒体运动和细胞器间的相互作用,包括与内质网的相互作用,也在细胞适应应激中起作用。在这篇综述中,我们讨论了压力如何影响这些组件,以及它们如何有助于复杂的适应性和病理反应,导致疾病。
Mitochondria sense and respond to many stressors and can support either cell survival or death through energy production and signaling pathways. Mitochondrial responses depend on fusion-fission dynamics that dilute and segregate damaged mitochondria. Mitochondrial motility and inter-organellar interactions, including with the endoplasmic reticulum, also function in cellular adaptation to stress. In this Review, we discuss how stressors influence these components, and how they contribute to the complex adaptive and pathological responses that lead to disease.
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