Perinatal exposure to ethanol in rats induces permanent disturbances of breathing and chemosensitivity during adulthood
Perinatal exposure to ethanol in rats induces permanent disturbances of breathing and chemosensitivity during adulthood
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DOI：
10.1016/j.neulet.2020.135219
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发表时间：
2020-09-14
影响因子：
2.5
通讯作者：
Pierrefiche, Olivier
中科院分区：
文献类型：
--
作者：
Dubois, Christophe J.;Pierrefiche, Olivier
众所周知，围产期暴露于滥用药物，包括酒精（乙醇），会影响呼吸功能的发育。然而，大多数研究描述了这些暴露的短期影响，主要集中在出生后的早期生活。在妊娠期和哺乳期暴露于乙醇后，我们先前已经表明，3-4周龄的大鼠在乙醇暴露结束时表现出慢性通气不足和对缺氧的反应改变。然而，这些缺陷是否是可逆的乙醇撤出后仍然未知。在这里，我们通过全身体积描记法研究了2个月大的大鼠从妊娠到断奶暴露于乙醇，随后一个月的乙醇戒断的呼吸活动。在乙醇戒断后，大鼠持续表现出呼吸频率显著降低，而潮气量无变化，这与较低的动脉血氧含量有关。此外，这些大鼠对缺氧的反应降低，而对高碳酸血症的反应保持不变。总之，围产期暴露于乙醇在大鼠中，不像暴露于可卡因，吗啡或尼古丁，其特征在于基础呼吸活动和化疗敏感性的选择性改变，持续很长一段时间后退出。
Perinatal exposure to drugs of abuse, including alcohol (ethanol), is known to impinge the development of respiratory function. However, most studies described the short-term effects of these exposures, focusing mostly on the early postnatal life. After exposure to ethanol during gestation and lactation we have previously shown that 3-4 week-old rat exhibit chronic hypoventilation and an altered response to hypoxia at the end of ethanol exposure. However, whether these deficits are reversible following ethanol withdrawal remained unknown. Here, we investigated through whole-body plethysmography the respiratory activity of 2 months-old rats exposed to ethanol from gestation to weaning followed by one month of ethanol withdrawal. After ethanol withdrawal, rats persistently exhibited a significant reduction in respiratory frequency without change in tidal volume associated to a lower arterial blood oxygen content. In addition, the response to hypoxia in these rats was reduced whereas the response to hypercapnia remained unaltered. In conclusion perinatal exposure to ethanol in rats, unlike exposure to cocaine, morphine or nicotine, is characterized by selective alterations of basal respiratory activity and chemosensitivity that persist long after withdrawal.