CLINICAL AND BACTERIOLOGICAL OBSERVATIONS OF A TOXIC SHOCK-LIKE SYNDROME DUE TO STREPTOCOCCUS-PYOGENES
CLINICAL AND BACTERIOLOGICAL OBSERVATIONS OF A TOXIC SHOCK-LIKE SYNDROME DUE TO STREPTOCOCCUS-PYOGENES
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DOI：
10.1056/nejm198707163170305
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发表时间：
1987-07-16
影响因子：
158.5
通讯作者：
TOMORY, GS
中科院分区：
文献类型：
--
作者：
CONE, LA;WOODARD, DR;TOMORY, GS
1978年，托德等人1描述了一种多系统临床综合征（中毒性休克综合征），其特征为突然出现发热、皮疹、呕吐和腹泻、低血压、结膜充血和草莓样舌，随后在恢复期间出现脱屑。该综合征与产毒素金黄色葡萄球菌的定植或感染有关。一种分子量为22，049的毒素，即中毒性休克综合征毒素-1，以前称为葡萄球菌肠毒素F或热原外毒素C，已被鉴定为引起该疾病的葡萄球菌产物。2 3 4 5所有三种毒素在化学和免疫学上都是相同的。近年来，葡萄球菌肠毒素B与非月经毒性的阴道炎有关。
IN 1978, Todd et al. 1 described a multisystem clinical syndrome (toxic shock syndrome) characterized by the sudden onset of fever, rash, vomiting and diarrhea, hypotension, conjunctival injection, and strawberry tongue, followed by desquamation during recovery. The syndrome has been associated with colonization or infection by a toxin-producing Staphylococcus aureus. A toxin with a molecular weight of 22,049, toxic shock syndrome toxin-1, formerly termed staphylococcal enterotoxin F or pyrogenic exotoxin C, has been identified as the staphylococcal product responsible for the disorder. 2 3 4 5 All three toxins are chemically and immunologically identical. Recently, staphylococcal enterotoxin B has been associated with nonmenstrual toxic...