An overview of the pharmacology, efficacy, safety and cost-effectiveness of lansoprazole.
An overview of the pharmacology, efficacy, safety and cost-effectiveness of lansoprazole.
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兰索拉唑的药理学、功效、安全性和成本效益概述。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Bown Rl
中科院分区：
文献类型：
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作者：
Bown Rl
兰索拉唑是一种质子泵抑制剂，通过抑制胃壁细胞中的H+/K+-腺苷三磷酸酶，以剂量依赖性方式减少胃酸分泌。它还表现出体外抗幽门螺杆菌的抗菌活性。在近10年的临床使用中，兰索拉唑已被证明对各种酸相关疾病有效且耐受性良好，包括胃食管反流病（GORD）、十二指肠溃疡、胃溃疡、非甾体抗炎药相关溃疡以及非溃疡性消化不良和酸分泌过多。它也与抗生素联合用于H。根除幽门在上述适应症中，兰索拉唑通常被证明上级优于组胺H2受体拮抗剂，并且至少与其他目前可用的质子泵抑制剂一样有效。本综述旨在评价兰索拉唑在酸相关疾病中的药理学、疗效、安全性和成本-效果，特别强调其在GORD和H。幽门螺杆菌根除方案。
Lansoprazole is a proton pump inhibitor that reduces gastric acid secretion in a dose-dependent manner via inhibition of H+/K+-adenosine triphosphatase in gastric parietal cells. It also exhibits antibacterial activity against Helicobacter pylori in vitro. During almost 10 years of clinical use, lansoprazole has proved effective and well tolerated in a wide range of acid-related disorders, including gastro-oesophageal reflux disease (GORD), duodenal ulcers, gastric ulcers, non-steroidal anti-inflammatory drug-related ulcers, as well as non-ulcer dyspepsia and acid hypersecretion. It is also used, in combination with antibiotics, for H. pylori eradication. In the above indications, lansoprazole has generally proved to be superior to the histamine H2-receptor antagonists, and is at least as effective as the other currently available proton pump inhibitors. This review aims to evaluate the pharmacology, efficacy, safety and cost-effectiveness of lansoprazole in acid-related disorders, with particular emphasis on its use in GORD and H. pylori eradication regimens.