Oncogenesis and cancer stem cells: current opinions and future directions.
Oncogenesis and cancer stem cells: current opinions and future directions.
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DOI：
10.1111/j.1582-4934.2008.00664.x
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发表时间：
2009-11
影响因子：
5.3
通讯作者：
O'Neill HC
中科院分区：
文献类型：
--
作者：
Cheng X;O'Neill HC
越来越多的证据表明，只有一部分癌细胞驱动肿瘤的生长和进展。这些细胞与正常干细胞具有相似的特性，被称为“癌症干细胞”。已通过细胞表面抗原的独特表达在急性髓性白血病和一些实体瘤中鉴定出癌症干细胞。它们的长期自我更新能力被认为是肿瘤维持和再生的决定性因素。对造血系统癌症的研究表明，正常造血的重要信号通路和基因，如Wnt、NF-κB、Notch、hedgehog (Hh)和Bmi1，具有致癌性，因此可能参与癌症干细胞的调控。消除肿瘤中的癌症干细胞可能会导致下游细胞的退化，这使它们成为新癌症疗法的潜在靶标。
There is increasing evidence to show that only a subset of cancer cells drives the growth and progression of a tumour. These cells share similar properties with normal stem cells and are termed ‘cancer stem cells’. Cancer stem cells have been identified in acute myeloid leukaemia and in some solid tumours by their distinct expression of cell surface antigens. Their long-term, self-renewing capacity is thought to be a determining factor in the maintenance and regrowth of the tumour. Studies on haematopoietic cancers show that important signalling pathways and genes for normal haematopoiesis, such as Wnt, NF-κB, Notch, hedgehog (Hh) and Bmi1, are oncogenic, thereby potentially involved in cancer stem cell regulation. Elimination of cancer stem cells in tumours could result in the degeneration of downstream cells, which makes them potential targets for new cancer therapies.