Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake).
Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake).
复制标题
口服灰树花（舞茸）子实体提取物具有抗肿瘤活性。
DOI：
10.1248/cpb.36.1819
复制
发表时间：
1988
影响因子：
1.7
通讯作者：
H. Kuroda
中科院分区：
文献类型：
--
作者：
I. Hishida;H. Nanba;H. Kuroda
从灰树花（Grifola frondosa，灰树花）的子实体中获得的酸不溶性、碱溶性、热水可提取的聚合物（一种含有约30%蛋白质的多糖；d部分）经小鼠口服后显示出抗同种异体和同基因肿瘤的活性。Winn实验检测了肿瘤生长抑制作用，结果显示口服d组分对肿瘤有完全抑制作用。这一事实表明，由荷瘤状态触发的免疫反应系统的刺激是由d -分数激活的。因此，我们检测了与免疫应答相关的细胞上d -分数的活性。显示抗原特异性细胞毒性的巨噬细胞或T细胞的细胞溶解活性和白细胞介素-1的生产能力增强。发现d-部分增强了与肿瘤生长抑制相关的延迟型超敏反应。
The acid-insoluble, alkali-soluble, hot-water-extractable polymer (a polysaccharide containing approximately 30% of protein; D-fraction) obtained from the fruit bodies of Grifola frondosa (maitake) exhibited antitumor activities against allogenic and syngeneic tumors on oral administration to mice. Winn assay conducted to examine the tumor growth-suppressing effect revealed a complete inhibition of the tumor by the oral administration of D-fraction. This fact indicates that stimulation of the immune response system triggered by the tumor-bearing state is activated by D-fraction. Consequently, the activity of D-fraction on cells associated with immune response was examined. The cytolytic activity and interleukin-1 productivity of macrophages or T cells which exhibit antigen-specific cytotoxicity were enhanced. D-fraction was found to potentiate the delayed-type hypersensitivity response which is associated with tumor growth suppression.