AN INVITRO AND INVIVO STUDY OF GLASS PARTICLES IN AMPULES
AN INVITRO AND INVIVO STUDY OF GLASS PARTICLES IN AMPULES
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DOI：
10.1002/jps.3030361002
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发表时间：
1947-01-01
期刊：
影响因子：
--
通讯作者：
DUNNING, JHF
中科院分区：
文献类型：
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作者：
BREWER, JH;DUNNING, JHF
本研究包括对接受静脉给药的家兔进行组织学研究。注射液。太阳能电池。在32天的时间内含有玻璃颗粒，表明安瓿制剂的偶尔颗粒污染。在动物中不产生显著的病理学。这表明需要大剂量才能在兔子身上产生任何病理反应。因此，通过仔细的安瓿处理，可以在很大程度上消除颗粒污染所固有的危险。
This investigation, which includes a histologic study of rabbits receiving intraven. injns. of solns. containing glass particles over a period of 32 days, indicates that occasional particle contamination of ampule prepns. produces no significant pathology in animals. It shows that massive doses are required to produce any pathological reaction in rabbits. Therefore, by careful ampule processing the dangers inherent in particle contamination can be largely eliminated.