Vogt-Koyanagi-Harada syndrome - current perspectives.
Vogt-Koyanagi-Harada syndrome - current perspectives.
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DOI：
10.2147/opth.s94866
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tomkins-Netzer O
中科院分区：
文献类型：
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作者：
Baltmr A;Lightman S;Tomkins-Netzer O
Vogt-Koyanagi-Harada综合征是非感染性全葡萄膜炎的一种原因，导致许多患者严重视力丧失。它是一种发生在遗传易感个体中的自身免疫性疾病，临床表现为双侧全葡萄膜炎，伴有浆液性视网膜脱离和充血肿胀的视盘，与神经和听觉表现相关。早期诊断和及时、充分的免疫抑制剂（皮质类固醇和其他免疫抑制药物）治疗可以阻止疾病进展，防止复发和视力丧失。本文综述了目前对这种疾病的临床变量方面的知识，突出诊断和治疗策略。
Vogt–Koyanagi–Harada syndrome is a cause of noninfectious panuveitis, leading to significant vision loss in many patients. It is an autoimmune disease occurring in genetically susceptible individuals and clinically presents as bilateral panuveitis with serous retinal detachments and hyperemic, swollen optic discs, which are associated with neurological and auditory manifestations. Early diagnosis and prompt and adequate treatment with immunosuppressive agents (corticosteroids and other immunosuppressive drugs) may halt disease progression and prevent recurrences and vision loss. This review summarizes the current knowledge on the variable clinical aspects of this disease, highlighting diagnostic and treatment strategies.