Demonstration of the genuine iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization.
Demonstration of the genuine iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization.
复制标题
证明睾丸生殖细胞肿瘤标准标记染色体的真正 iso-12p 特征，并通过竞争性原位杂交鉴定进一步的 12 号染色体畸变。
DOI：
--
复制
发表时间：
1991
影响因子：
9.8
通讯作者：
A. Vankessel
中科院分区：
文献类型：
--
作者：
Rf Suijkerbuijk;Ay Vandeveen;J. Vanechten;C. Buys;B. Dejong;J. Oosterhuis;Da Warburton;J. Cassiman;D. Schonk;A. Vankessel
应用竞争原位杂交技术对睾丸生殖细胞肿瘤(TGCT)的12号染色体进行了分析。两个啮齿动物-人类体细胞杂交的DNA被用作探针，其中包含正常的12号染色体或12号染色体的p臂作为其独特的人类材料。我们的结果证明了标准标记染色体在TGCT中具有真正的iso-12p特征。此外，还鉴定了代表易位产物的变异标记，这些易位产物也涉及12号染色体。
The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.
DOI：
10.1073/pnas.83.9.2934
发表时间：
1986-05-01
影响因子：
11.1
作者：
PINKEL, D;STRAUME, T;GRAY, JW
通讯作者：
GRAY, JW
来自人类类淋巴母细胞微细胞融合的单染色体啮齿动物-人类杂交体，含有插入的显性选择标记。
影响因子：
4.4
作者：
Warburton,D;Gersen,S;Yu,MT;Jackson,C;Handelin,B;Housman,D
通讯作者：
Housman,D