Significance of transforming growth factor β1 as a new tumor marker for colorectal cancer
Significance of transforming growth factor β1 as a new tumor marker for colorectal cancer
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DOI：
10.1002/ijc.1631
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发表时间：
2002-02-01
影响因子：
6.4
通讯作者：
Kitajima, M
中科院分区：
文献类型：
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作者：
Narai, S;Watanabe, M;Kitajima, M
转化生长因子β 1 （tgf - β 1）被认为与癌症的生长和进展有关。tgf - β在以潜伏形式分泌后转变为活性形式。我们的目的是阐明结直肠癌患者血浆中活性和总tgf - β 1浓度的意义。采用ELISA法测定了45例结直肠癌患者和23名健康志愿者血浆中活性tgf - β 1和总tgf - β 1的浓度，并测定了活化率（活性tgf - β 1与总tgf - β 1的比值）。结直肠癌患者血浆中活性tgf - β 1浓度（21.9+/-12.8 pg/ml）显著高于健康志愿者(9.9+/-5.9 pg/ml
Transforming growth factor beta1 (TGF-beta1) is thought to be involved in cancer growth and progression. TGF-beta1 changes to its active form after being secreted in its latent form. Our aim was to clarify the significance of plasma concentrations of active and total TGF-beta1 of patients with colorectal cancer. Plasma concentrations of active and total TGF-beta1 in 45 patients with colorectal cancer and 23 healthy volunteers were measured using ELISA and the activation rate (ratio of active to total TGF-beta1) was determined. Plasma concentrations of active TGF-beta1 (21.9+/-12.8 pg/ml) were significantly higher in patients with colorectal cancer than in healthy volunteers (9.9+/-5.9 pg/ml; p