Rho GTPases in platelet function.
Rho GTPases in platelet function.
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DOI：
10.1111/jth.12051
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
McCarty OJ
中科院分区：
文献类型：
--
作者：
Aslan JE;McCarty OJ
GTP结合蛋白的Rho家族-通常也称为Rho GTP酶-是血小板细胞骨架和血小板功能的主要调节剂。这些低分子量或“小”GTP酶在信号从血小板细胞表面受体到驱动血小板功能的细胞内信号传导途径的空间和时间转导和放大中充当信号传导开关。Rho GT3家族成员RhoA、Cdc 42和Rac 1已成为血小板中肌动蛋白细胞骨架动力学的关键调节因子，并在血小板聚集、分泌、扩散和血栓形成中发挥关键作用。Rho GTP酶调节剂，包括GEF和GAP以及下游效应物，如WASP、formins和PAK，也可以调节血小板活化和功能。在这篇综述中，我们提供了一个概述Rho GTdR信号在血小板生理学。Rho GTP酶和血小板的研究有着共同的历史，因为血小板已作为表征Rho功能的理想的非转化细胞模型。同样，最近对Rho GTPases家族成员的细胞生物学的研究有助于建立对血小板功能的分子调节的理解，并将通过进一步表征Rho GTPases以及Rho GAP、GEF、RhoGDI和Rho效应物在肌动蛋白重组和其他Rho驱动的细胞过程中继续这样做。
The Rho family of GTP binding proteins – also commonly referred to as the Rho GTPases – are master regulators of the platelet cytoskeleton and platelet function. These low molecular weight or “small” GTPases act as signaling switches in the spatial and temporal transduction and amplification of signals from platelet cell surface receptors to the intracellular signaling pathways that drive platelet function. The Rho GTPase family members RhoA, Cdc42 and Rac1 have emerged as key regulators in the dynamics of the actin cytoskeleton in platelets and play key roles in platelet aggregation, secretion, spreading and thrombus formation. Rho GTPase regulators, including GEFs and GAPs and downstream effectors, such as the WASPs, formins and PAKs, may also regulate platelet activation and function. In this review, we provide an overview of Rho GTPase signaling in platelet physiology. Studies of Rho GTPases and platelets have had a shared history, as platelets have served as an ideal, non-transformed cellular model to characterize Rho function. Likewise, recent studies of the cell biology of Rho GTPase family members have helped to build an understanding of the molecular regulation of platelet function and will continue to do so through the further characterization of Rho GTPases as well as Rho GAPs, GEFs, RhoGDIs and Rho effectors in actin reorganization and other Rho-driven cellular processes.
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DOI：
10.1038/nrm2867
发表时间：
2010-04
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1161/atvbaha.112.254920
发表时间：
2012-11
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Delaney MK;Liu J;Zheng Y;Berndt MC;Du X
通讯作者：
Du X
影响因子：
4.8
作者：
Bahou, WF;Scudder, L;Jesty, J
通讯作者：
Jesty, J
影响因子：
4.8
作者：
Belisle, B;Abo, A
通讯作者：
Abo, A
DOI：
10.1016/j.biocel.2006.11.011
发表时间：
2007-01-01
影响因子：
4
作者：
Bernard, Ora
通讯作者：
Bernard, Ora