Is maternal smoking during pregnancy associated with an increased risk of congenital heart defects among offspring? A systematic review and meta-analysis of observational studies
Is maternal smoking during pregnancy associated with an increased risk of congenital heart defects among offspring? A systematic review and meta-analysis of observational studies
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母亲在怀孕期间吸烟是否会增加后代先天性心脏病的风险？
DOI：
10.1080/14767058.2016.1183640
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发表时间：
2017-03-01
影响因子：
1.8
通讯作者：
Li, Xiaohong
中科院分区：
文献类型：
--
作者：
Zhang, Dongyu;Cui, Hao;Li, Xiaohong
目的：探讨母亲怀孕期间吸烟与后代先天性心脏病（CHD）风险之间的关系。方法：检索 PubMed、EMBASE 和 Web of Science 中符合条件的研究。感兴趣的结果包括任何 CHD 和九种亚型的风险。我们总结了研究特征，并在荟萃分析中使用了随机效应模型，并利用两阶段剂量反应模型来评估吸烟量与风险之间的关联。通过 Cochrane Q 统计量和 I 平方值的卡方检验评估统计异质性。采用漏斗图和Egger检验评估发表偏倚，存在发表偏倚时采用修剪填充法。结果：纳入43项观察性流行病学研究。任何 CHD 的汇总风险比 (RR) 均为 1.11 (95% CI: 1.04, 1.18)，但表现出显着的统计异质性 (p
Objective: To investigate the association between maternal smoking during pregnancy and risk of congenital heart defects (CHDs) among offspring.Methods: PubMed, EMBASE, and Web of Science were searched for eligible studies. The outcomes of interest included risk of any CHD and nine subtypes. We summarized study characteristics and used a random-effects model in meta-analysis, and a two-stage dose-response model was utilized to assess the association between smoking consumption and risk. Statistical heterogeneity was assessed by a chi-squared test of the Cochrane Q statistic and I-squared value. Publication bias was assessed by funnel plots and Egger's test, and trim and fill method was utilized when publication bias existed.Results: Forty-three observational epidemiologic studies were included. The pooled risk ratio (RR) of any CHD was 1.11 (95% CI: 1.04, 1.18), but it exhibited substantial statistical heterogeneity (p