RISK-FACTORS FOR OPEN-ANGLE GLAUCOMA - THE BARBADOS EYE STUDY
RISK-FACTORS FOR OPEN-ANGLE GLAUCOMA - THE BARBADOS EYE STUDY
复制标题
DOI：
10.1001/archopht.1995.01100070092031
复制
发表时间：
1995-07-01
影响因子：
--
通讯作者：
GEORGE, TW
中科院分区：
文献类型：
--
作者：
LESKE, MC;CONNELL, AMS;GEORGE, TW
目的：评估巴巴多斯眼科研究中黑人参与者患开角型青光眼的危险因素。设计：基于人口的人口学、医学、眼科、家族和其他可能与开角型青光眼相关的因素的研究。背景和参与者：巴巴多斯眼科研究包括 4709 名巴巴多斯居民，这些居民是通过对巴巴多斯出生的公民进行简单随机抽样确定的，年龄为 40 至 84 岁；参与率为84%。该报告基于在研究现场检查的 4314 名黑人参与者； 302 例 (7%) 符合巴巴多斯眼科研究开角型青光眼的标准。数据收集：标准化方案包括压平眼压测量、汉弗莱视野测量、眼底摄影、血压、人体测量和访谈。对符合特定标准的参与者进行眼科检查。 主要结果指标：开角型青光眼的定义是存在特征性视野缺损和视盘损伤。通过逻辑回归分析评估开角型青光眼与特定因素的关联。结果：年龄、男性、高眼压和开角型青光眼家族史是主要危险因素；男性的后一种关联比女性更强。去脂体重和白内障史是与开角型青光眼相关的唯一其他因素。尽管高血压和糖尿病在巴巴多斯眼科研究参与者中很常见，但它们与开角型青光眼的患病率无关。然而，发现与低舒张压-眼压差以及低收缩压和舒张压/眼内压比值相关。结论：在巴巴多斯眼科研究黑人群体中，最有可能患有开角型青光眼的人是老年男性，并且有开角型青光眼家族史、高眼压、瘦体重和白内障史。这些结果表明可能的遗传或家族因素在开角型青光眼中的重要性。血管危险因素的作用与我们发现的低血压与眼压关系一致，但该结果可以用开角型青光眼的高眼压来解释。
Objective: To evaluate risk factors for open-angle glaucoma among black participants in the Barbados Eye Study.Design: Population-based study of demographic, medical, ocular, familial, and other factors possibly related to open-angle glaucoma.Setting and Participants: The Barbados Eye Study included 4709 Barbados residents identified by a simple random sample of Barbadian-born citizens, 40 to 84 years of age; participation was 84%. This report is based on the 4314 black participants examined at the study site; 302 (7%) met the Barbados Eye Study criteria for open-angle glaucoma.Data Collection: A standardized protocol included applanation tonometry, Humphrey perimetry, fundus photography, blood pressure, anthropometry, and an interview. An ophthalmologic examination was performed for participants who met specific criteria.Main Outcome Measures: Open-angle glaucoma was defined by the presence of both characteristic visual field defects and optic disc damage. Association of open-angle glaucoma with specific factors was evaluated in logistic regression analyses.Results: Age, male gender, high intraocular pressure, and family history of open-angle glaucoma were major risk factors; the latter association was stronger in men than women. Lean body mass and cataract history were the only other factors related to open-angle glaucoma. Although hypertension and diabetes were common in Barbados Eye Study participants, they were unrelated to the prevalence of open-angle glaucoma. However, associations were found with low diastolic blood pressure-intraocular pressure differences and low systolic and diastolic blood pressure/intraocular pressure ratios.Conclusions: In the Barbados Eye Study black population, persons most likely to have open-angle glaucoma were older men and had a family history of open-angle glaucoma, high intraocular pressure, lean body mass, and cataract history. These results suggest the importance of possible genetic or familial factors in open-angle glaucoma. The role of vascular risk factors is consistent with our finding of low blood pressure to intraocular pressure relationships, but the results could be explained by the high intraocular pressure in open-angle glaucoma.