The stepping motor protein as a feedback control ratchet
The stepping motor protein as a feedback control ratchet
复制标题
DOI：
10.1016/j.biosystems.2006.07.013
复制
发表时间：
2007-04-01
期刊：
影响因子：
1.6
通讯作者：
Bier, Martin
中科院分区：
文献类型：
--
作者：
Bier, Martin
解释了从单头运动蛋白到步进双头运动蛋白如何等同于从随机闪烁棘轮到反馈控制棘轮。文献中对这两种棘轮进行了深入研究，并对它们的速度和效率进行了简要回顾。接下来展示反馈控制棘轮机制模型如何解释在驱动蛋白上获得的非常准确的最新数据。最后，讨论了内摩擦在步进电机蛋白质运行中的作用。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
It is explained how going from a one headed motor protein to a stepping two headed motor protein is equivalent to going from a stochastically flashing ratchet to a feedback control ratchet. Both these ratchets have been well studied in the literature and their speeds and efficiencies are briefly reviewed. Next it is shown how a feedback control ratchet mechanism model can account for very accurate recent data obtained on kinesin. Finally, the role of internal friction in the operation of stepping motor proteins is discussed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.